On June 20, 2024, the Astros announced that they would be promoting Bloss to the majors for the first time to make his MLB debut the next day.[4][5] He was officially selected to the 40-man and active rosters the following day.[6] In his debut against the Baltimore Orioles, Bloss allowed two runs on six hits with two strikeouts across 3+2⁄3 innings. He was placed on the injured list the next day with right shoulder discomfort.[7]