The trail starts at Brasstown Bald and heads in a southernly direction along the boundary between Union and Towns counties. After 2.2 miles (3.5 km) and a descent of nearly 1,500 feet (460 m), it reaches Jacks Gap and crosses Georgia State Route 180. Shortly after reaching Jacks Gap, Jacks Knob Trail enters the Mark Trail Wilderness. The trails ends at an intersection with the Appalachian Trail below the peak of Jacks Knob at an elevation of about 3,550 feet (1,080 m).