Interleukin 28 receptor, alpha subunit

IFNLR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OG4, 3OG6, 5IXI, 5IXD
Identifiers
Aliases	IFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2, Interleukin 28 receptor, alpha subunit, interferon lambda receptor 1
External IDs	OMIM: 607404; MGI: 2429859; HomoloGene: 52086; GeneCards: IFNLR1; OMA:IFNLR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 24,154,168 bp[1] End 24,187,959 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 135,413,598 bp[2] End 135,435,492 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa buccal mucosa cell right lobe of liver testicle mucosa of sigmoid colon cerebellar vermis duodenum cerebellar hemisphere lymph node Top expressed in granulocyte urethra jejunum transitional epithelium of urinary bladder middle ear lip ileum duodenum esophagus Hindgut More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine receptor activity protein binding Cellular component integral component of membrane interleukin-28 receptor complex membrane plasma membrane Biological process response to type III interferon mucosal immune response defense response to virus negative regulation of cell population proliferation regulation of defense response to virus by host cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 163702 242700 Ensembl ENSG00000185436 ENSMUSG00000062157 UniProt Q8IU57 Q8CGK5 RefSeq (mRNA) NM_170743 NM_173064 NM_173065 NM_174851 RefSeq (protein) NP_734464 NP_775087 NP_775088 NP_777276 Location (UCSC) Chr 1: 24.15 – 24.19 Mb Chr 4: 135.41 – 135.44 Mb PubMed search [3] [4]
Wikidata
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Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000185436 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062157 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)".