IL17RC

IL17RC
Identifiers
Aliases	IL17RC, IL17-RL, IL17RL, CANDF9, interleukin 17 receptor C
External IDs	OMIM: 610925; MGI: 2159336; HomoloGene: 15894; GeneCards: IL17RC; OMA:IL17RC - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3|3p25.3-p24.1 Start 9,917,074 bp[1] End 9,933,630 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E3 Start 113,448,388 bp[2] End 113,460,101 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right adrenal cortex right lobe of liver gastric mucosa left adrenal cortex skin of abdomen skin of leg muscle layer of sigmoid colon apex of heart right lobe of thyroid gland Top expressed in ileum jejunum lip esophagus colon zone of skin urinary bladder white adipose tissue duodenum humerus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-17 receptor activity signaling receptor binding Cellular component integral component of membrane cell surface integral component of plasma membrane membrane plasma membrane Biological process positive regulation of cytokine production involved in inflammatory response granulocyte chemotaxis defense response to fungus interleukin-17-mediated signaling pathway cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84818 171095 Ensembl ENSG00000163702 ENSMUSG00000030281 UniProt Q8NAC3 Q8K4C2 RefSeq (mRNA) NM_001203263 NM_001203264 NM_001203265 NM_032732 NM_153460 NM_153461 NM_153462 NM_153463 NM_001367278 NM_001367279 NM_001367280 NM_134159 NM_178942 RefSeq (protein) NP_001190192 NP_001190193 NP_001190194 NP_116121 NP_703190 NP_703191 NP_001354207 NP_001354208 NP_001354209 NP_598920 NP_849273 Location (UCSC) Chr 3: 9.92 – 9.93 Mb Chr 6: 113.45 – 113.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-17 receptor C is a protein that in humans is encoded by the IL17RC gene.^[5][6]

Function

This gene encodes a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.^[6]

See also

• Interleukin-17 receptor

References

1. GRCh38: Ensembl release 89: ENSG00000163702 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030281 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haudenschild D, Moseley T, Rose L, Reddi AH (February 2002). "Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer". The Journal of Biological Chemistry. 277 (6): 4309–16. doi:10.1074/jbc.M109372200. PMID 11706037.
6. "Entrez Gene: IL17RC interleukin 17 receptor C".

Further reading

• Gerritsen ME, Tomlinson JE, Zlot C, Ziman M, Hwang S (October 2003). "Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells". British Journal of Pharmacology. 140 (4): 595–610. doi:10.1038/sj.bjp.0705494. PMC 1574080. PMID 14504135.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Haudenschild DR, Curtiss SB, Moseley TA, Reddi AH (September 2006). "Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA". The Prostate. 66 (12): 1268–74. doi:10.1002/pros.20422. PMID 16688746. S2CID 25101473.
• Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J (July 2006). "Cutting edge: interleukin 17 signals through a heteromeric receptor complex". Journal of Immunology. 177 (1): 36–9. doi:10.4049/jimmunol.177.1.36. PMID 16785495.
• Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD (October 2007). "Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F". Journal of Immunology. 179 (8): 5462–73. doi:10.4049/jimmunol.179.8.5462. PMC 2849293. PMID 17911633.

External links

• IL17RC+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.