Humouse

A humouse is an immunodeficient mouse reconstituted with a human immune system, also generally known as humanised mouse. Although conventional mouse models have

Humouse

A humouse is an immunodeficient mouse reconstituted with a human immune system, also generally known as humanised mouse. Although conventional mouse models have allowed for an increased understanding of mammalian immune systems, this knowledge cannot necessarily be directly applied to humans due to biological differences between the two species.[1]

Humice could theoretically be used as novel pre-clinical models of the human immune system, with uses including assessing vaccine efficacy.[2][3][4]

See also

References

  1. ^ Hughes, Christopher C. W.; Mestas, Javier (2004-03-01). "Of Mice and Not Men: Differences between Mouse and Human Immunology". The Journal of Immunology. 172 (5): 2731–2738. Bibcode:2004JImm..172.2731M. doi:10.4049/jimmunol.172.5.2731. ISSN 1550-6606. PMID 14978070.
  2. ^ "Baylor Institute for Immunology Research (BIIR): Humouse". Archived from the original on 2010-12-15.
  3. ^ https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01202/full
  4. ^ Schönrich G, Raftery MJ (2017). "Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System". Frontiers in Immunology. 8 1202. doi:10.3389/fimmu.2017.01202. PMC 5622932. PMID 29018450.
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