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No study has led to the isolation of true human sex pheromones, although various researchers have investigated the possibility of their existence.^[1]^[2]

Pheromones, in general, are secreted chemical substances by organisms that trigger a social reaction in the same species. Sex pheromones are a special type of olfactory signal, produced to attract the opposite sex, to encourage mating or to perform some other function closely related to sexual reproduction. While humans are highly dependent upon visual cues, smells can also play a role in sociosexual behaviors. An inherent difficulty in studying human pheromones is the need for cleanliness and odorlessness in human participants.^[3]

Experiments have focused on three classes of putative human sex pheromones: axillary steroids, vaginal aliphatic acids and stimulators of the vomeronasal organ.

Axillary steroids are produced by the testicles, ovaries, apocrine glands and adrenal glands.^[4] These chemicals are not biologically active until puberty when sex steroids influence their activity.^[5] The activity change during puberty suggests that humans communicate through odors.^[4] Several axillary steroids have been described as possible human pheromones: androstadienol, androstadienone, androstenone, androstenol, and androsterone.

Androstenol is the putative female pheromone.^[5] In a 1978 study by Kirk-Smith, people wearing surgical masks treated with androstenol or untreated were shown pictures of people, animals and buildings and asked to rate their attractiveness.^[6] Individuals with their masks treated with androstenol rated their photographs as being "warmer" and "more friendly".^[6] The best-known case study involves the synchronization of menstrual cycles among women based on unconscious odor cues, the McClintock effect, named after the primary investigator, Martha McClintock, of the University of Chicago.^[7]^[8] A group of women were exposed to a whiff of perspiration from other women. Depending on the time in the month the sweat was collected (before, during, or after ovulation), there was an association with the recipient woman's menstrual cycle to speed up or slow down. The 1971 study proposed two types of pheromones involved: "One, produced prior to ovulation, shortens the ovarian cycle; and the second, produced just at ovulation, lengthens the cycle". However, recent studies and reviews of the methodology have called the validity of her results into question.^[9]^[10] A 2013 meta-review of existing studies showed that the syncing of ovarian cycles likely did not exist.^[11]

Androstenone is postulated to be secreted only by men as an attractant for women and is also thought to affect their mood positively. It seems to have different effects on women, depending on where a female is in her menstrual cycle, with the highest sensitivity to it during ovulation.^[5] In 1983, study participants exposed to androstenone were shown to undergo changes in skin conductance.^[12] Androstenone has been found to be perceived as more pleasant to women at a woman's time of ovulation. It is hypothesized that this may be a way for a male to detect an ovulating female who would be more willing to be involved in sexual interaction.^[1]^[2]^[3]^[13]

References

^ ^a ^b Wysocki, Charles J.; Preti, George (7 October 2004). "Facts, fallacies, fears, and frustrations with human pheromones". The Anatomical Record. 281A (1): 1201–1211. doi:10.1002/ar.a.20125. PMID 15470677. It is emphasized that no bioassay-guided study has led to the isolation of true human pheromones, a step that will elucidate specific functions to human chemical signals.
^ ^a ^b Riley, Alex (9 May 2016). "Pheromones are probably not why people find you attractive". BBC News. Retrieved 2016-05-09.
^ ^a ^b Grammer, Karl; Fink, Bernhard; Neave, Nick (2005). "Human pheromones and sexual attraction". European Journal of Obstetrics and Gynecology and Reproductive Biology. 118 (2): 135–142. doi:10.1016/j.ejogrb.2004.08.010. PMID 15653193.
^ ^a ^b Hays, Warren S. T. (2003). "Human pheromones: have they been demonstrated?". Behavioral Ecology and Sociobiology. 54 (2): 89–97. Bibcode:2003BEcoS..54...89H. doi:10.1007/s00265-003-0613-4. JSTOR 25063239. S2CID 37400635.
^ ^a ^b ^c Mostafa, Taymour; Khouly, Ghada El; Hassan, Ashraf (2012). "Pheromones in sex and reproduction: Do they have a role in humans?". Journal of Advanced Research. 3 (1): 1–9. doi:10.1016/j.jare.2011.03.003.
^ ^a ^b Kirk-Smith, Michael (1978). "Human social attitudes affected by androstenol". Research Communications in Psychology, Psychiatry & Behavior. 3 (4): 379–384. ISSN 0362-2428.
^ McClintock, M.K. (January 1971). "Menstrual synchrony and suppression". Nature. 229 (5282): 244–5. Bibcode:1971Natur.229..244M. doi:10.1038/229244a0. PMID 4994256. S2CID 4267390.
^ Stern, K., McClintock. M.K. (March 1998). "Regulation of ovulation by human pheromones". Nature. 392 (6672): 177–9. Bibcode:1998Natur.392..177S. doi:10.1038/32408. PMID 9515961. S2CID 4426700.{{cite journal}}: CS1 maint: multiple names: authors list (link).
^ Yang, Zhengwei; Schank, Jeffrey C. (2006). "Women Do Not Synchronize Their Menstrual Cycles". Human Nature. 17 (4): 434–447. doi:10.1007/s12110-006-1005-z. PMID 26181612. S2CID 2316864. Retrieved 2007-06-25.
^ Strassmann BI (March 1999). "Menstrual synchrony pheromones: cause for doubt". Hum. Reprod. 14 (3): 579–80. doi:10.1093/humrep/14.3.579. PMID 10221677.
^ Harris, Amy L.; Vitzthum, Virginia J. (2013-04-01). "Darwin's Legacy: An Evolutionary View of Women's Reproductive and Sexual Functioning". The Journal of Sex Research. 50 (3–4): 207–246. doi:10.1080/00224499.2012.763085. ISSN 0022-4499. PMID 23480070. S2CID 30229421.
^ Toller, C. Van; Kirk-Smith, M.; Wood, N.; Lombard, J.; Dodd, G.H. (1983). "Skin conductance and subjective assessments associated with the odour of 5-α-androstand-3-one". Biological Psychology. 16 (1–2): 85–107. doi:10.1016/0301-0511(83)90056-X. PMID 6682682. S2CID 54325922.
^ Stromberg, Joseph (13 March 2015). "How one perfume company misled scientists into believing in human sex pheromones". Vox. Retrieved 23 July 2015. ... But the basic truth is that we have no evidence human pheromones even exist — and these studies can all be traced back to a single fragrance company called Erox that managed to convince dozens of scientists their two 'pheromones' were worth researching in the first place.