In 2015, Ese'ese graduated to the Canterbury-Bankstown Bulldogs' New South Wales Cup team.[6] In Round 7 of the 2015 NRL season, he made his NRL debut for the Canterbury-Bankstown club against the Manly Warringah Sea Eagles.[7][8] He was contracted to the Bulldogs until the end of 2016,[9] however, after being stood down in April due to a drink driving charge,[10] he was released from the final year of his contract.[11] Late in the year, he signed with the Souths Logan Magpies in the Queensland Cup for 2016, while training with the Brisbane Broncos during the 2016 pre-season.[11]
Brisbane Broncos (2016-2017)
In 2016, after gaining a contract with the Brisbane Broncos during the pre-season, Ese'ese made his Brisbane debut against South Sydney in Round 8 of the season.[12][13] In September, he re-signed with the Brisbane club on a two-year contract until the end of 2018.[14]
Ese’ese earned a starting spot at prop over Korbin Sims in some matches.[15] On 6 May, Ese’ese made his international debut for Samoa against England, playing off the interchange bench in the 30–10 loss at Campbelltown Stadium.[16][17]
In round 1 of the 2018 season, Ese'ese made his debut for Newcastle in their 19–18 golden point extra-time win over the Manly Warringah Sea Eagles.[20]
In the 2019 NRL season,Ese'ese played 18 games for Newcastle as the club finished 11th on the table for a second consecutive year.[21]
Gold Coast Titans (2021-2022)
In July 2020, Ese'ese signed a two-year contract with the Gold Coast Titans starting in 2021.[22]
In round 10 of the 2021 NRL season, he was sent off for a high tackle during the Gold Coast's 48–12 loss against Penrith.[23]
Following the Gold Coast's decision not to extend Ese'ese's contract, former coach from the Brisbane Broncos, Wayne Bennett signed him to the Dolphins for the 2023 NRL season.[24]
He played a total of 13 games for the Gold Coast in the 2022 NRL season as the club finished 13th on the table.[25]
On 15 August 2023, Ese'ese signed a three-year deal to join English side Hull F.C. starting in 2024.[26]
Ese'ese made his club debut for Hull F.C. against arch-rivals Hull Kingston Rovers in round 1 of the 2024 Super League season. He was sent to the sin bin during the first half of the match for a dangerous high tackle. Hull F.C. would go on to lose the match 22-0.[27]