Notorious serial killer Jonathan Chambers has been captured and detained by Sheriff Berger. Chambers is executed in the electric chair, but the police do not know that he survived by making a deal with the devil. His body is transported to a hospital for an autopsy examination.
Meanwhile, Sara Wexler is a lonely teenager who attempts to commit suicide by running in front of a car. However, she is only injured before being discovered by Berger who takes her to hospital. At the hospital Chambers now has supernatural powers and begins to slaughter everyone in the hospital, including Berger.
Sara and another teenager called Walter, who was sent to hospital after accidentally being impaled on his own rake, try to escape from the hospital but find that all exits are locked. Chambers then confronts Sara and explains that he needs her to help him because she has a power which will make him immortal. She declines the offer and flees from him. Eventually she defeats Chambers by opening a portal to hell and sending him through it. In the final scene, however, it is revealed that Chambers's personality has passed into her.
