A 2017 umbrella review of meta-analyses found that drinking coffee is generally safe within usual levels of intake and is more likely to improve health outcomes than to cause harm at doses of 3 or 4 cups of coffee daily. Exceptions include possible increased risk in women having bone fractures, and a possible increased risk in fetal loss or decreased birth weight during pregnancy.[2] Results were complicated by poor study quality, and differences in age, gender, health status, and serving size.[2]
In some people, coffee induces defecation within minutes of consumption.[5][6][7][8] However, the specific mechanism of action and chemical constituents responsible are still unknown.[9]
Mortality
A 2014 meta-analysis found that coffee consumption (4 cups/day) was inversely associated with all-cause mortality (a 16% lower risk), as well as cardiovascular disease mortality specifically (a 21% lower risk from drinking 3 cups/day), but not with cancer mortality[10] with exception being oral cancer mortality.[11]
Additional meta-analyses corroborated these findings, showing that higher coffee consumption (2–4 cups per day) was associated with a reduced risk of death by all disease causes.[12][13]
A 2012 meta-analysis concluded that people who drank moderate amounts of coffee had a lower rate of heart failure, with the biggest effect found for those who drank more than four cups a day.[15] A 2014 meta-analysis concluded that cardiovascular disease, such as coronary artery disease and stroke, is less likely with three to five cups of non-decaffeinated coffee per day, but more likely with over five cups per day.[16] A 2016 meta-analysis showed that coffee consumption was associated with a reduced risk of death in patients who have had a myocardial infarction.[17]
The effect of no or moderate daily consumption of coffee on risk for developing hypertension has been assessed in several reviews during the 21st century. A 2019 review found that one to two cups consumed per day had no effect on hypertension risk, whereas drinking three or more cups per day reduced the risk,[18] a finding in agreement with a 2017 analysis which showed a 9% lower risk of hypertension with long-term consumption of up to seven cups of coffee per day.[19] Another review in 2018 found that the risk of hypertension was reduced by 2% with each one cup per day increment of coffee consumption up to 8 cups per day, compared with people who did not consume any coffee.[20]
A large 2024 study,[21] involving close to two hundred thousand participants using the UK Biobank, indicated that a habitual caffeine intake, at moderate levels of 200 mg - 300 mg of caffeine per day "was associated with a lower risk of new-onset CM [Cardiometabolic multimorbidity] and could play important roles in almost all transition phases of CM development." In particular, the study found that metabolites related to very low-density lipoproteins were reduced with higher metabolites related to high-density lipoproteins. The study found any caffeine intake in general reduced risks of CM, although did not find strong evidence that tea reduced the risk of stroke and Type 2 Diabetes.
By contrast, a 2011 review had found that drinking one to three cups of coffee per day may pose a slightly increased risk of developing hypertension.[22]
The 2021 European Society of Cardiology Guidelines on Cardiovascular Disease Prevention in Clinical Practice state: "Non-filtered coffee contains LDL-C-raising cafestol and kahweol, and may be associated with an up to 25% increased risk of atherosclerosis (ASCVD) mortality by consumption of nine or more drinks a day. Non-filtered coffee includes boiled, Greek, and Turkish coffee and some espresso coffees. Moderate coffee consumption (3–4 cups per day) is probably not harmful, perhaps even moderately beneficial".[23]
Parkinson's disease
Meta-analyses have consistently found that long-term coffee consumption is associated with a lower risk of Parkinson's disease.[2]
Type II diabetes
In a systematic review and meta-analysis of 28 prospective observational studies, representing over one million participants, every additional cup of caffeinated and decaffeinated coffee consumed in a day was associated, respectively, with a 9% and 6% lower risk of type 2 diabetes.[24]
Cancer
Meta-analyses on the effects of coffee consumption on cancer risk are inconclusive.[25][26][27]
The World Health Organization's 2016 IARC Monograph "found no conclusive evidence for a carcinogenic effect of drinking coffee" but found that drinking very hot beverages probably causes cancer of the oesophagus.[28]
The UK National Health Service advises that avoiding coffee may reduce anxiety.[30] In chronic psychiatric patients, caffeine, the major active ingredient in coffee, is associated with anxiety.[31][32] At high doses, typically greater than 300 mg, caffeine can both cause and worsen anxiety.[33] For some people, discontinuing caffeine use can significantly reduce anxiety.[34]Caffeine-induced anxiety disorder is a subclass of substance- or medication-induced anxiety disorder.[35] Populations that may be most impacted by caffeine consumption are adolescents and people with anxiety disorders.[36] Preliminary research indicated the possibility of a beneficial relationship between coffee intake and reduced depression.[2][37][38] Long-term preliminary research, including assessment of symptoms for dementia and cognitive impairment, was inconclusive for coffee having an effect in the elderly, mainly due to the poor quality of the studies.[2][39]
^Cornwall, Hannah L.; Edwards, Ben A.; Curran, John F.; Boyce, Stephen (May 2020) [2019-06-13]. "Coffee to go? The effect of coffee on resolution of ileus following abdominal surgery: A systematic review and meta-analysis of randomised controlled trials". Clinical Nutrition. 39 (5): 1385–1394. doi:10.1016/j.clnu.2019.06.003. PMID31253438. S2CID195766007.
^Grosso, Giuseppe; Micek, Agnieszka; Castellano, Sabrina; Pajak, Andzrej; Galvano, Fabio (January 2016) [2015-10-31]. "Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies". Molecular Nutrition & Food Research. 60 (1): 223–234. doi:10.1002/mnfr.201500620. PMID26518745.
^Panza, Francesco; Solfrizzi, Vincenzo; Barulli, Maria Rosaria; Bonfiglio, Caterina; Guerra, Vito; Osella, Alberto Rubén; Seripa, Davide; Sabbà, Carlo; Pilotto, Alberto; Logroscino, Giancarlo (March 2015) [December 2014]. "Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review". The Journal of Nutrition, Health & Aging. 19 (3): 313–328. doi:10.1007/s12603-014-0563-8. hdl:11586/145493. PMID25732217. S2CID8376733.
Further reading
Folmer, Britta; Farah, Adriana; Jones, Lawrence; Fogliano, Vincenzo (2017). "Chapter 20. Human Wellbeing - Sociability, Performance, and Health: 20.4. Coffee and Health". Written at Nestlé Nespresso SA, Switzerland. In Folmer, Britta; Blank, Imre; Farah, Adriana; Giuliano, Peter; Sanders, Dean; Wille, Chris (eds.). The Craft and Science of Coffee (1 ed.). London, UK: Academic Press / Elsevier Inc. pp. 506–510. ISBN978-0-12-803520-7. Archived(PDF) from the original on 2024-07-05. Retrieved 2024-02-15. (xxvi+529+5 pages)
Strategi Solo vs Squad di Free Fire: Cara Menang Mudah!
