Hagan Bayley

Hagan Bayley
Born
John Hagan Pryce Bayley

(1951-02-13) 13 February 1951 (age 73)[3]
Wales, UK
Alma mater
Known for
AwardsFRS (2011)[1]
Scientific career
FieldsChemical Biology
Institutions
ThesisAdamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (1979)
Doctoral advisorJeremy Knowles[2]
Websitebayley.chem.ox.ac.uk

John Hagan Pryce Bayley FRS, FLSW (born 13 February 1951[3]) is a British scientist, who holds the position of Professor of Chemical Biology at the University of Oxford.[5][6][7][8][9]

Life and education

Bayley was educated at The King's School, Chester and [3] Uppingham School, before going to Balliol College, Oxford in 1970 [10] and Harvard University, where he was awarded a Ph.D. in 1979.[2][11]

Originally from Wales, he spent much of his early career between the United Kingdom and the United States.[12]

Research

Bayley's research is largely based on the study and engineering of transmembrane pore-forming proteins,[13] as well as interests in chemical signal transduction and biomolecular materials.[14] He is the co-founder of Oxford Nanopore Technologies Ltd. Bayley's research includes work on the pore-forming protein alpha haemolysin[15] engineered for sensing has been highly cited.[16]

Career

Following his PhD, Bayley completed postdoctoral research at Massachusetts Institute of Technology.[2] He previously held appointments at Columbia University, University of Massachusetts Medical School, and Texas A&M University.[2] Bayley has been based at the University of Oxford since 2003 and is a fellow of Hertford College, Oxford.[17]

Awards and honours

Bayley was elected a Fellow of the Royal Society in 2011.[1] His nomination reads

Hagan Bayley's achievements lie at the interface between chemistry and biology. He has used protein chemistry, organic chemistry, and biophysics to explore the folding, assembly, and function of transmembrane channels and pores. These studies have led to the development of protein pores as "nanoreactors", with which both non-covalent and covalent chemistry of single molecules can be examined. Applications of this methodology have included host–guest interactions and step-by-step polymer growth. Based on this work, Bayley has developed "stochastic sensing," which has been shown with a wide variety of analytes to reveal both concentration and identity through single-molecule detection.[1]

In 2012, Bayley was elected as a Fellow of the Learned Society of Wales.[18]

The Science Council recognised him as "one of the UK's 100 leading practising scientists" of 2014.[19]

References

  1. ^ a b c "Hagan Bayley". The Royal Society.
  2. ^ a b c d "CURRICULUM VITAE Hagan Bayley" (PDF). Retrieved 26 February 2018.
  3. ^ a b c d "BAYLEY, Prof. (John) Hagan (Pryce)". Who's Who. Vol. 2014 (online edition via Oxford University Press ed.). A & C Black. (Subscription or UK public library membership required.)
  4. ^ Branton, D.; Deamer, D. W.; Marziali, A.; Bayley, H.; Benner, S. A.; Butler, T.; Di Ventra, M.; Garaj, S.; Hibbs, A.; Huang, X.; Jovanovich, S. B.; Krstic, P. S.; Lindsay, S.; Ling, X. S.; Mastrangelo, C. H.; Meller, A.; Oliver, J. S.; Pershin, Y. V.; Ramsey, J. M.; Riehn, R.; Soni, G. V.; Tabard-Cossa, V.; Wanunu, M.; Wiggin, M.; Schloss, J. A. (2008). "The potential and challenges of nanopore sequencing". Nature Biotechnology. 26 (10): 1146–1153. doi:10.1038/nbt.1495. PMC 2683588. PMID 18846088.
  5. ^ http://bayley.chem.ox.ac.uk/ Bayley group at the University of Oxford
  6. ^ http://research.chem.ox.ac.uk/hagan-bayley.aspx Archived 26 April 2011 at the Wayback Machine Hagan Bayley Research page
  7. ^ Hagan Bayley's publications indexed by the Scopus bibliographic database. (subscription required)
  8. ^ Braha, O.; Braha, H.; Conlan, L. Q.; Cheley, S.; Bayley, S. (1999). "Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter". Nature. 398 (6729): 686–690. Bibcode:1999Natur.398..686G. doi:10.1038/19491. PMID 10227291. S2CID 4366779.
  9. ^ Lou, H; Chen, M; Black, S. S.; Bushell, S. R.; Ceccarelli, M; Mach, T; Beis, K; Low, A. S.; Bamford, V. A.; Booth, I. R.; Bayley, H; Naismith, J. H. (2011). "Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. Coli". PLOS ONE. 6 (10): e25825. Bibcode:2011PLoSO...625825L. doi:10.1371/journal.pone.0025825. PMC 3203869. PMID 22053181.
  10. ^ Balliol College Register (Fifth ed.). 1983. p. 457.
  11. ^ Bayley, Hagan (1979). Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (PhD thesis). Harvard University. ProQuest 302912373.
  12. ^ Bayley2009-05-29T18:07:20+01:00, Hagan. "Nanopores for thought". Chemistry World. Retrieved 22 January 2021.{{cite web}}: CS1 maint: numeric names: authors list (link)
  13. ^ Howorka, S.; Cheley, S.; Bayley, H. (2001). "Sequence-specific detection of individual DNA strands using engineered nanopores". Nature Biotechnology. 19 (7): 636–639. doi:10.1038/90236. PMID 11433274. S2CID 447980.
  14. ^ Bayley, Hagan Profile at the University of Oxford Archived 17 January 2010 at the Wayback Machine
  15. ^ Song, L.; Hobaugh, M. R.; Shustak, C.; Cheley, S.; Bayley, H.; Gouaux, J. E. (1996). "Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore". Science. 274 (5294): 1859–1865. Bibcode:1996Sci...274.1859S. doi:10.1126/science.274.5294.1859. PMID 8943190. S2CID 45663016.
  16. ^ Hagan Bayley publications indexed by Google Scholar
  17. ^ Bayley, Hagan Profile at Hertford College
  18. ^ Wales, The Learned Society of. "Hagan Bayley". The Learned Society of Wales. Retrieved 22 August 2023.
  19. ^ "The UK's 100 leading practising scientists". 17 January 2014.


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