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oxidase (glycolate oxidase) 1 is a protein that in humans is encoded by the HAO1 gene. This gene is one of three related genes that have 2-hydroxyacid oxidase...
Click to read more »Givosiran Givlaari ALAS1 Acute hepatic porphyria GalNAc (SC) Lumasiran Oxlumo HAO1 Primary hyperoxaluria type 1 GalNAc (SC) Inclisiran Leqvio PCSK9 Hypercholesterolaemia...
Click to read more »hepatokines. Other liver-specific proteins are certain liver enzymes such as HAO1 and RDH16, proteins involved in bile synthesis such as BAAT and SLC27A5,...
Click to read more »eggshells. This linkage is further evidenced by the fact that two of the genes, HAO1 and BMP2, affecting medullary bone (the part of the bone that transfers calcium...
Click to read more »(siRNA) that reduces levels of glycolate oxidase (GO) enzyme by targeting the HAO1 messenger ribonucleic acid (mRNA) in hepatocytes through RNA interference...
Click to read more »levels through RNAi by targeting hydroxyacid oxidase 1 (HAO1) mRNA for breakdown. Lowering HAO1 enzyme levels reduces the oxidation of glycolate to glyoxylate...
Click to read more »Genes known to contain IREs include FTH1, FTL, TFRC, ALAS2, Sdhb, ACO2, Hao1, SLC11A2 (encoding DMT1), NDUFS1, SLC40A1 (encoding the ferroportin) CDC42BPA...
Click to read more »HGNC:15598; P81172 6902 HAND1 HGNC:4807; O96004 6903 HAND2 HGNC:4808; P61296 6904 HAO1 HGNC:4809; Q9UJM8 6905 HAO2 HGNC:4810; Q9NYQ3 6906 HAP1 HGNC:4812; P54257...
Click to read more »Vachier-Lagrave (FRA), 2722 (J09) Leinier Domínguez (CUB), 2719 (R) Wang Hao1 (CHN), 2718 (R) Peter Leko (HUN), 2717 (R) Alexander Moiseenko (UKR), 2715...
Click to read more »editor to liver cells through lipid nanoparticles, accurately editing the HAO1 gene to inhibit the expression of glycolate oxidase, thereby reducing oxalate...
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