Arana was promoted to Corinthians' main squad after the 2014 Copa São Paulo de Futebol Júnior final and was an unused substitute in twelve matches of the 2014 Campeonato Brasileiro Série A.[1][2]
On 12 August 2015, Arana made his Corinthians debut as a substitute during half-time in a 4–3 win against Sport Recife at Arena Corinthians. He was directly responsible for the second goal of Sport, as he made a wrong pass that was intercepted and resulted in a goal. He compensated for the mistake by creating the opportunity that resulted in a penalty kick, which gave Corinthians the victory.[6] He made his first league start in the away game against Avaí on 16 August.[7] On 6 September, Arana scored his first goal in a 3–3 away draw against Corinthians' biggest rival Palmeiras.[8]
Sevilla
On 7 December 2017, Arana transferred to Spanish club Sevilla on a deal worth 12 million euros and signed a four-and-a-half-year contract.[9] He joined the squad upon the opening of the winter transfer window in January 2018.
Atalanta (loan)
On 28 August 2019, Arana joined Italian club Atalanta on a season-long loan with the option to buy.[10]
Atlético Mineiro
On 29 January 2020, Arana joined Atlético Mineiro on an 18-month loan deal, which included an obligatory purchase clause.[11]
International career
Arana represented Brazil at the 2017 South American U-20 Championship. Arana also represented the under-23 team in 2019, playing in friendlies against South American rivals Chile and Colombia, ahead of the CONMEBOL Olympic Qualifying Championship (in which he did not take part) and the Summer Olympics originally scheduled for 2020, now being held in 2021.