Gmina Pajęczno is an urban-rural gmina (administrative district) in Pajęczno County, Łódź Voivodeship, in central Poland. Its seat is the town of Pajęczno, which lies approximately 78 kilometres (48 mi) south-west of the regional capital Łódź.
The gmina covers an area of 113.44 square kilometres (43.8 sq mi), and as of 2006 its total population is 11,655 (out of which the population of Pajęczno amounts to 6,674, and the population of the rural part of the gmina is 4,981).