Glomeruloid hemangioma

Glomeruloid hemangioma
SpecialtyDermatology

Glomeruloid hemangioma is a distinctive vascular tumor first described in 1990 when found to be associated with POEMS syndrome and Castleman disease.[1][2] Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules.

Signs and symptoms

Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules.[3] They mostly reside on the trunk and proximal limbs and range in size from a few millimeters to a few centimeters in diameter.[4][5] There have also been rare reports of glomeruloid hemangioma impacting the face.[6][7] There have also been reports of eruptive angiomatous lesions, which resemble eruptive histiocytomas.[8]

Causes

Glomeruloid hemangiomas are most commonly associated with POEMS syndrome, occurring in up to 45% of individuals with POEMS syndrome.[9] Glomeruloid hemangiomas have also been associated with TAFRO syndrome.[10] Rarely glomeruloid hemangiomas can occur in individuals with no systematic conditions.[11]

Diagnosis

The histopathologic examination displays well-defined, dispersed dermal structures in different sizes that have resemblance to renal glomeruli. The central vessel is bigger and has a sinusoidal appearance, and it is surrounded by a network of small capillary vessels on the periphery.[12]

See also

References

  1. ^ James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "28. Dermal and subcutaneous tumors". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 594. ISBN 978-0-323-54753-6.
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  3. ^ Gupta, Jyoti; Kandhari, Rajat; Ramesh, V; Singh, Avninder (2013). "Glomeruloid hemangioma in normal individuals". Indian Journal of Dermatology. 58 (2). Medknow: 160. doi:10.4103/0019-5154.108088. ISSN 0019-5154. PMC 3657245. PMID 23716835.
  4. ^ Puig, Lluis; Moreno, Abelardo; Domingo, Pere; Llistosella, Enric; de Moragas, José M. (1985). "Cutaneous angiomas in POEMS syndrome". Journal of the American Academy of Dermatology. 12 (5). Elsevier BV: 961–964. doi:10.1016/s0190-9622(85)70123-5. ISSN 0190-9622. PMID 3158680.
  5. ^ Chan, P. T.; Lee, K. C.; Chong, L. Y.; Lo, K. K.; Cheung, Y. F. (2006). "Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome". Clinical and Experimental Dermatology. 31 (6). Oxford University Press (OUP): 775–777. doi:10.1111/j.1365-2230.2006.02213.x. ISSN 0307-6938. PMID 17040261.
  6. ^ Tsai, Chang-Yu; Lai, Chan-Ho; Chan, Heng-Leong; Kuo, Tseng-tong (2001). "Glomeruloid hemangioma –- a specific cutaneous marker of POEMS syndrome". International Journal of Dermatology. 40 (6). Wiley: 403–406. doi:10.1046/j.1365-4362.2001.01246-2.x. ISSN 0011-9059. PMID 11589746.
  7. ^ Yang, Seong Gyu; Cho, Kwang Hyun; Bang, Yung-Jue; Kim, Chul Woo (1998). "A Case of Glomeruloid Hemangioma Associated With Multicentric Castleman's Disease". The American Journal of Dermatopathology. 20 (3). Ovid Technologies (Wolters Kluwer Health): 266–270. doi:10.1097/00000372-199806000-00008. ISSN 0193-1091. PMID 9650700.
  8. ^ Perniciaro, Charles (1995). "POEMS syndrome". Seminars in Dermatology. 14 (2). Elsevier BV: 162–165. doi:10.1016/s1085-5629(05)80013-6. ISSN 0278-145X. PMID 7640197.
  9. ^ Mocellin, Simone (2021). "Glomeruloid Hemangioma". Soft Tissue Tumors. Cham: Springer International Publishing. pp. 377–378. doi:10.1007/978-3-030-58710-9_112. ISBN 978-3-030-58709-3.
  10. ^ Shinozaki-Ushiku, Aya; Higashihara, Takaaki; Ikemura, Masako; Sato, Junichiro; Nangaku, Masaomi; Ushiku, Tetsuo; Fukayama, Masashi (2018). "Glomeruloid hemangioma associated with TAFRO syndrome". Human Pathology. 82. Elsevier BV: 172–176. doi:10.1016/j.humpath.2018.04.011. ISSN 0046-8177. PMID 29702119.
  11. ^ Roy, Rita R; Shimada, Katsumitsu; Hasegawa, Hiromasa (2022-01-29). "A Case of Oral Glomeruloid Hemangioma Without Systemic Conditions". Cureus. 14 (1): e21705. doi:10.7759/cureus.21705. ISSN 2168-8184. PMC 8803383. PMID 35145824.
  12. ^ Hernández Aragüés, I.; Pulido Pérez, A.; Ciudad Blanco, C.; Parra Blanco, V.; Suárez Fernández, R. (2017). "Glomeruloid Hemangioma and POEMS Syndrome". Actas Dermo-Sifiliográficas (English Edition). 108 (2). Elsevier BV: e15–e19. doi:10.1016/j.adengl.2016.12.006. ISSN 1578-2190.

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