Her mother was accused of infidelity with Ugo d'Este, Ginevra's half-brother and he and Parisina were condemned to death by Niccolò when Ginevra was aged six. Five years later Niccolò remarried to Ricciarda di Saluzzo, giving Ginevra two other half-brothers (Ercole and Sigismondo), in addition to her father's other illegitimate children.
On her death in 1440 she was buried in the Tempio Malatestiano.[4] In 1461 Pope Pius II accused Pandolfo of several crimes, including killing Ginevra, and excommunicated him.[5]