Her mystery novels were all set in the Southern United States and frequently featured a female protagonist. The protagonist would become involved with a dangerous male figure during the course of the story. The locations of the novels matched those in her life. Her early novels were set on Southern farms similar to the one she grew up on near Tupelo. Her last was set in Midtown Atlanta, where she spent the last years of her career and life.
In addition to her mystery novels, Pou was a literary celebrity in Atlanta during the 1960s, 1970s and 1980s. She frequently wrote articles for local magazines and contributed to Atlanta public-affairs television shows. She was well known as a philanthropist and frequent contributor to liberal and feminist political causes.