GR-45809

GR-45809

Identifiers
IUPAC name 2-(3,4-Dichloro-phenyl)-1-(7-pyrrolidin-1-ylmethyl-1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-ethanone
CAS Number	138154-97-9^Y
PubChem CID	9955378
ChemSpider	8130988
Chemical and physical data
Formula	C20H26Cl2N2O3
Molar mass	413.34 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C1CCN(C1)CC2CC3(CCN2C(=O)CC4=CC(=C(C=C4)Cl)Cl)OCCO3
InChI InChI=1S/C20H26Cl2N2O3/c21-17-4-3-15(11-18(17)22)12-19(25)24-8-5-20(26-9-10-27-20)13-16(24)14-23-6-1-2-7-23/h3-4,11,16H,1-2,5-10,12-14H2 Key:LWUQHEXXEFUHHQ-UHFFFAOYSA-N

GR-45809 is a kappa opioid receptor (KOR) agonist with use in the treatment of pain.^[1][2] It was developed over 30 years ago. It has a structure that is similar to ZT-52656A.

References

1. Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD (January 1991). "(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics". Journal of Medicinal Chemistry. 34 (1): 397–403. doi:10.1021/jm00105a061. PMID 1846921.
2. Scopes DI, Hayes NF, Bays DE, Belton D, Brain J, Brown DS, Judd DB, McElroy AB, Meerholz CA, Naylor A (February 1992). "New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus". Journal of Medicinal Chemistry. 35 (3): 490–501. doi:10.1021/jm00081a009. PMID 1310743.