GAS2L1

GAS2L1
Identifiers
Aliases	GAS2L1, GAR22, growth arrest specific 2 like 1
External IDs	OMIM: 602128; MGI: 1926176; GeneCards: GAS2L1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	29,312,785 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,015,327 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; tendon of biceps brachii; ; seminal vesicula; ; endothelial cell; ; Region I of hippocampus proper; ; dorsal motor nucleus of vagus nerve; ; olfactory bulb; ; Brodmann area 23; ; primary visual cortex; ; parotid gland;
	Top expressed in
	otic vesicle; ; blood; ; lip; ; seminiferous tubule; ; internal carotid artery; ; olfactory epithelium; ; skin of external ear; ; external carotid artery; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytoskeletal anchor activity; thyroid hormone receptor binding; microtubule binding;
Cellular component	cytoplasm; microtubule; cytoskeleton; stress fiber;
Biological process	cellular response to starvation; negative regulation of microtubule depolymerization; negative regulation of cell growth; microtubule bundle formation; negative regulation of gene expression; negative regulation of erythrocyte differentiation; cellular response to thyroid hormone stimulus; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10634
	78926
	ENSG00000185340
	ENSMUSG00000034201
	Q99501
	Q8JZP9
NM_001278730; NM_006478; NM_152236; NM_152237; NM_001362985;
	NM_001395196; NM_001395197
	NM_001190406; NM_001190408; NM_030228; NM_144560
	NP_001265659; NP_006469; NP_689422; NP_689423; NP_001349914
	NP_001177335; NP_001177337; NP_084504; NP_653146
	Wikidata
View/Edit Human	View/Edit Mouse

GAS2-like protein 1 is a protein that in humans is encoded by the GAS2L1 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185340 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034201 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zucman-Rossi J, Legoix P, Thomas G (Mar 1997). "Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region". Genomics. 38 (3): 247–54. doi:10.1006/geno.1996.0625. PMID 8975699.
^ Goriounov D, Leung CL, Liem RK (Feb 2003). "Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules". J Cell Sci. 116 (Pt 6): 1045–58. doi:10.1242/jcs.00272. PMID 12584248.
^ Brancolini C, Bottega S, Schneider C (Jul 1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.
^ ^a ^b "Entrez Gene: GAS2L1 growth arrest-specific 2 like 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185340 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034201 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8975699-5] Zucman-Rossi J, Legoix P, Thomas G (Mar 1997). "Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region". Genomics. 38 (3): 247–54. doi:10.1006/geno.1996.0625. PMID 8975699.

[pmid12584248-6] Goriounov D, Leung CL, Liem RK (Feb 2003). "Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules". J Cell Sci. 116 (Pt 6): 1045–58. doi:10.1242/jcs.00272. PMID 12584248.

[pmid1607387-7] Brancolini C, Bottega S, Schneider C (Jul 1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493. PMID 1607387.

[entrez-8] "Entrez Gene: GAS2L1 growth arrest-specific 2 like 1".

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GAS2L1

References

Further reading

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