When his father died in 1706, according to his will, he inherited the duchy of Saxe-Meiningen with his older full-brother, Ernst Ludwig I, and his younger half-brother, Anton Ulrich.
But, shortly after, Ernst Ludwig signed a contract between himself and his brothers, and they were compelled to leave full control of the duchy in his hands.
When Ernst Ludwig died (1724), Friedrich Wilhelm and Anton Ulrich took again the government of the duchy as guardians of his nephews until 1733.
After the death of his nephew, Karl Frederick (1743), he inherited the duchy of Saxe-Meiningen.
Friedrich Wilhelm never married and died after only three years of reigning. He was succeeded by his younger half-brother, Anton Ulrich.
Ancestors
Ancestors of Friedrich Wilhelm, Duke of Saxe-Meiningen
Hannelore Schneider: Das Herzogtum Sachsen-Meiningen unter seinen ersten Herzögen. In: Verona Gerasch (Red.): Beiträge zum Kolloquium: 300 Jahre Schloss Elisabethenburg (= Südthüringer Forschungen. Bd. 27, ISSN0585-8720). Staatliche Museen, Meiningen 1994, S. 12–19.
Ludwig Hertel: Meiningische Geschichte von 1680 bis zur Gegenwart (= Schriften des Vereins für Sachsen-Meiningische Geschichte und Landeskunde. Heft 47, ZDB-ID513329-4 = Neue Landeskunde des Herzogtums Sachsen-Meiningen. Heft 10). Gadow & Sohn, Hildburghausen 1904, Digitalisat.