The son of the general manager of Brooklyn's Peter Cooper Glue Factory, Fackenthal graduated from the borough's Boys High School in 1902 before earning his undergraduate degree (as a self-described "able C man") from Columbia College in 1906.[4][5] As a student, his prodigious administrative abilities (reflected by his leadership in various campus organizations, including the Varsity Show and the Columbia Daily Spectator) were recognized by president Nicholas Murray Butler, leading to his appointment as chief clerk (1906–1910), secretary (1910–1937), and provost (1937–1948) of the university. As secretary and provost, he was the de facto administrator of the Pulitzer Prizes' non-journalistic awards from their inception until 1948; following his retirement, he received a special Prize in recognition of his service.[6]
Between the retirement of Nicholas Murray Butler in 1945 and the installation of Dwight D. Eisenhower as president in 1948, Fackenthal served as acting president while retaining his post as provost. Although several trustees considered motioning for his permanent appointment (in part due to his longstanding popularity among the undergraduate student body), this was forestalled by the ailing Butler, who considered Fackenthal to be unworthy of the position. Despite this acrimony, Fackenthal was elected to the university's board of trustees against Butler's wishes in 1946 in an unprecedented breach of longstanding tradition.[8] According to Pulitzer Prizes staff member Sean Murphy, Fackenthal developed a plan for Columbia's continued growth during this period that was "largely eschewed by his successors," presaging the tumult of Grayson Kirk's administration and the Columbia University protests of 1968. He also oversaw the formation of the School of General Studies (for nontraditional undergraduates and nonmatriculated students), the graduate-level School of International Affairs and the Harriman Institute.[9]
Following his retirement from the university in 1948, he served as educational consultant to the Carnegie Corporation (1948–1952) and then as president of Columbia University Press (1953–1958). He also served as president of the Bushwick Savings Bank and remained a trustee of various institutions, including Columbia, Barnard College, Franklin and Marshall College and the Riverdale Country School. His speeches as acting president were published by Columbia University Press as The Greater Power and Other Addresses (1949).
In December 1965, he was critically injured when his car collided with a truck in White Township, New Jersey, 35 miles south of his country home in Buck Hill Falls, Pennsylvania. As a result of his injuries, Fackenthal (who never married and had no legitimate children) was forced to permanently relocate from Brooklyn to Buck Hill Falls. He relinquished his trusteeship of Columbia in 1967 and died at Monroe County General Hospital in East Stroudsburg, Pennsylvania, on September 5, 1968.[10]