Francisco Santos

Francisco Santos may refer to:

• Francisco Dos Santos (born 1974), Brazilian footballer
• Francisco Santos (swimmer, born 1962), Angolan/Portuguese swimmer, artist and writer, also known as Xesko
• Francisco Santos (swimmer, born 1998), Portuguese swimmer
• Francisco Santos (baseball) (born 1974), former Major League Baseball outfielder
• Francisco Santos (footballer) (born 1904), Portuguese footballer
• Francisco Santos Calderón (born 1961), Colombian politician and journalist
• Francisco Santos Leal (born 1968), Spanish mathematician
• Francisco Cabrera Santos (1946–2010), mayor of Valencia, Carabobo, Venezuela
• Francisco Santos, Piauí, a municipality in the state of Piauí, Brazil
• Francisco O. Santos, Filipino nutritionist and biochemist