Left a widower with two small daughters who are looked after by his widowed mother, Dr Pellegrin is a general practitioner in the city of Arles. At a party he sees a handsome and assured widow, Armande, who decides to be his next wife. Though she capably takes over his house, his children and the administration of his practice, the relationship lacks passion. He meets a forward young woman, Martine, who has come to Arles to find work, and after an evening's drinking spends the night with her in a hotel.
Under a transparent story of her being referred to him as a patient, he introduces her into his house. Armande is sympathetic to the girl and suggests that she can work as Pellegrin's assistant, the pay enabling her to live in lodgings. Amid the constraints of his job and his marriage, Pellegrin snatches moments with Martine when he can, but if she has a drink or a dance with anyone else he becomes insanely jealous.
Unable to take the strain of this artificial life with no future, in a strange town where everybody knows the doctor and where his wife must by now know all, Martine decides to get out. Pellegrin rushes home to pack a bag and join her, but cannot find her at the railway station. Walking home despondent, he sees her say goodbye to a man in a bar and get on a bus. Shattered, he returns to his welcoming wife.