Laboratory and clinical research in the transplantation of the liver, lungs, and small intestines; studies in physiology, most notably in transplantation biology and in the physiology of shock
Fikri Alican (2 April 1929 – 19 August 2015) was a Turkish scientist and physician with various contributions to medical science, ranging from organ transplantation to physiology.[a]
Early life and career
Alican was born in Adapazarı, a city in northwestern Turkey, 150 km east of Istanbul. He left his hometown after middle school, attending high school and college in Istanbul, where he graduated from Robert College with a B.S. (1949) and from Istanbul University with an M.D. (1955).[b][1] He did his residency at the Istanbul University Medical Center's Clinic of Treatment and Exploratory Surgery, also known as Surgical Clinic #4, headed by Şinasi Hakkı Erel.[2] It is there that he met his future wife, Halide Ihlamur, later Halide Alican, a surgical nurse working at the same clinic.[3]
After completing his residency in general surgery at Istanbul University, his growing interest in the field of organ transplantation, then in its heyday, took him to Jackson, Mississippi, where he joined the University of Mississippi team leading the world in transplantation research, including the first lung transplant (11 June 1963) and the first heart transplant (23 January 1964), under the leadership of James D. Hardy.[c][4] A few weeks after his arrival there in the summer of 1960, he proposed to Ihlamur, as he always called her, even after she took his name and dropped hers, and they got married in Jackson in November 1960, remaining married for fifty-five years (1960–2015) until his death at age eighty-six.[5] He also obtained a master's degree (M.S., 1962) in physiology at the University of Mississippi, studying with Arthur C. Guyton, while working as a research fellow (soon to become a research associate) in Hardy's department of surgery.[6]
Best known for his work in organ transplantation, though with some notable initiatives in physiology as well, Alican later established a successful private practice as a general surgeon. His professional career was divided between medical research in the United States and private practice in Turkey.
Main Contributions
Alican's main contributions came in the 1960s (1960–1971) when he worked at the University of Mississippi Medical Center (UMMC) in the pioneering days of laboratory research and clinical studies in organ transplantation.[7][8] His research focused largely on the lungs[9][10][11][12][13][14][15][16][17][18][19] and on the liver,[20][21][22][23][24][25][26][27] though he is also known for his work on intestinal transplantation.[28] He performed the first ever simultaneous bilateral lung transplantation in canines, one of many such operations paving the way for the procedure in humans.[15][16][17][18][19]
His role in the development of surgical techniques in transplantation was complemented by his work in physiology,[29][30][31][32][33] including transplantation biology in general[34] as well as a particular specialty in the physiology of shock.[35][36][37][38]
Relocating to Istanbul in 1971, he held a professorship in surgery at Istanbul University until 1979, turning to private practice upon the institution of legal and regulatory changes barring academic physicians from working outside the university.[39] At the time of his departure from the University of Mississippi, he was an attending surgeon at the university hospital as well as associate director of the transplantation program there.[40] Twenty years later, he became a founding member ("fellow") of the James D. Hardy Society[permanent dead link], established in 1991.[41][42]
He has published extensively both in English and in Turkish. His journal articles, mostly in English, are almost exclusively in the areas of organ transplantation and physiology. His monographs, all in Turkish, are more diverse, ranging from general surgery to organ transplantation to cancer research and the in-depth study of various other diseases. The division mirrors the transformation of his career from medical research in the United States to general surgery in Turkey.
His autobiography (2000/2007) describes that transformation as coming with a natural obstacle to research: the relative scarcity of institutional resources in Turkey at that time.[43] He notes that this not only held back progress in laboratory and clinical studies but also impeded scholarly initiatives inevitably undermined by the inadequacy of academic libraries. The solution he reports having implemented is the creation and maintenance of his own library, complete with a card catalog, populated with entries from leading medical journals acquired with his own funds.[44] Specifically, he reports having maintained personal subscriptions to twenty-two medical journals for over thirty years.[d] He identifies these periodical holdings, supplemented by the selective acquisition of books on an ongoing but less regular schedule, as the main flow of information for the wall-to-wall card catalog in his office where he would personally enter the bibliographic details of each article in every issue. Alican credits this makeshift system for enabling him to publish a combined total of 3,000 pages on top of his output in the United States.[e][47]
Selected publications
Books
Date
Publication
1960
Alican, Fikri (1960). Anesteziyoloji: Ameliyata Hazırlık, Ameliyat, Ameliyat Sonrası [Anesthesiology: Preoperative Preparation, Surgery, Postoperative Care]. 750 Yataklı Çamlıca Askeri Göğüs Hastalıkları Hastenesi Yayınları No. 2. Istanbul: 750 Yataklı Çamlıca Askeri Göğüs Hastalıkları Hastenesi.
1968
Alican, Fikri (1968). Ameliyata Hazırlık, Anestezi, Ameliyat Sonrası Bakımı [Preoperative Preparation, Anesthesia, Postoperative Care]. Istanbul: Kasımpaşa Deniz Hastanesi Yayınevi.[f]
1968
Alican, Fikri (1968). Transplantasyon Biyolojisi: Hızla Gelişmekte Olan Yeni Bir Bilim [Transplantation Biology: A Rapidly Developing New Science]. Istanbul: İstanbul Üniversitesi Tıp Fakültesi.
1981
Alican, Fikri (1981). Meme Kanseri [Breast Cancer]. Istanbul: Avrupa Tıp Kitapçılık.
1993
Alican, Fikri (1993). Kanser [Cancer]. Istanbul: Avrupa Tıp Kitapçılık. Second, enlarged and updated edition, 1997.
1993
Alican, Fikri (1993). Meme Hastalıkları [Diseases of the Breast]. Istanbul: Avrupa Tıp Kitapçılık.
1993
Alican, Fikri (1993). Transplantasyon [Transplantation]. Istanbul: Avrupa Tıp Kitapçılık.
1994–1995
Alican, Fikri (1994–1995). Cerrahi Dersleri [Lectures in Surgery]. Vol. Three volumes. Istanbul: Dünya Tıp Kitabevi.
1996
Alican, Fikri (1996). Meme Kanseri: Değişen Kavramlar ve Güncel Tedaviler [Breast Cancer: Changing Conceptions and Current Treatments]. Istanbul: Avrupa Tıp Kitapçılık.
2000
Alican, Fikri (2000). Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak]. Istanbul: Doğan Kitap. ISBN978-9-7567-7047-4. Second, revised and enlarged edition with pictures published by Nobel Tıp Kitabevleri, 2007. ISBN978-9-7542-0574-9 [Autobiography.]
2007
Alican, Fikri (2007). Genel Cerrahi [General Surgery]. Vol. Two volumes. Istanbul: Nobel Tıp Kitabevleri. ISBN978-9-7542-0532-9 (vol. 1). ISBN978-9-7542-0533-6 (vol. 2). [Compilation of the author's previous books on medicine.][g]
Articles
Date
Publication
1961
Alican, Fikri; Hardy, James D. (December 1961). "Mechanisms of Shock as Reflected in Studies of Lymph of Abdominal Organs". Surgery, Gynecology & Obstetrics. 113: 743–756. ISSN0039-6087. PMID13860423.
1961
Alican, Fikri; Hardy, James D. (1961). "Relationship and Significance of the Levels of Direct Bilirubin, Indirect Bilirubin, and Alkaline Phosphatase in Lymph, Blood, and Urine After Ligation of the Common Bile Duct". Surgical Forum. 12: 337–339. ISSN0071-8041. PMID13860424.
1961
Hardy, James D.; Alican, Fikri (July 1961). "Ischemic Gangrene without Major Organic Vascular Occlusion: An Enlarging Concept". Surgery. 50 (1): 107–114. ISSN0039-6060. PMID13711520.
1962
Alican, Fikri (March 1962). "A Sensitive Method for Recording Lymph Flow: Observations on the Dynamics of Hepatosplanchnic Blood and Lymph". The Journal of Surgical Research. 2 (2): 104–109. doi:10.1016/S0022-4804(62)80004-3. ISSN0022-4804. PMID13860425.
1962
Alican, Fikri (August 1962). "Pathophysiology of Endotoxin Shock: Clinical Observations and Experimental Studies". The American Journal of the Medical Sciences. 244 (2): 237–257. doi:10.1097/00000441-196208000-00014. ISSN0002-9629. PMID13860426.
1962
Alican, Fikri; Hardy, James D. (August 1962). "Lymphatic Transport of Bile Pigments and Alkaline Phosphatase in Experimental Common Duct Obstruction". Surgery. 52 (2): 366–372. ISSN0039-6060. PMID13860422.
1962
Alican, Fikri; Hardy, James D. (1962). "Sympatho-Adrenal System in Endotoxin Shock". Surgical Forum. 13: 8–10. ISSN0071-8041. PMID14012021.
1962
Alican, Fikri; Dalton, Jr., Martin L.; Hardy, James D. (June 1962). "Experimental Endotoxin Shock: Circulatory Changes with Emphasis upon Cardiac Function". The American Journal of Surgery. 103 (6): 702–708. doi:10.1016/0002-9610(62)90249-0. ISSN0002-9610. PMID13860421.
Hardy, James D.; Alican, Fikri (1966). "Lung Transplantation". Advances in Surgery. 2: 235–264. ISSN0065-3411. PMID5333296.
1967
Alican, Fikri (1967). "Experimental Orthotopic Liver Transplantation: Experience with 150 Dogs". New Istanbul Contribution to Clinical Science. 9 (3): 71–98. ISSN0028-5447. PMID16300153.
1967
Alican, Fikri (April 1967). "Köpekte Total Hepatektomiden Sonra Karaciğerin Tekrar Yerine Takılması [Replantation of the Liver in Dogs Following Total Hepatectomy]". Türk Tıp Cemiyeti Mecmuası. 33 (4): 209–226. ISSN0494-2736. PMID4863470.
1967
Alican, Fikri (May 1967). "Eksperimantal Karaciğer Homotransplantasyonu [Experimental Liver Homotransplantation]". Türk Tıp Cemiyeti Mecmuası. 33 (5): 296–311. ISSN0494-2736.
1967
Alican, Fikri; Hardy, James D. (June 1967). "Eksperimantal Akciğer Transplantasyonu: Teknik, Fizyolojik ve İmmünolojik Problemler [Experimental Lung Transplantation: Technical, Physiological and Immunological Problems]". Türk Tıp Cemiyeti Mecmuası. 33 (6): 319–329. ISSN0494-2736. PMID4865363.
1967
Alican, Fikri; Hardy, James D. (August 1967). "Replantation of the Liver in Dogs". The Journal of Surgical Research. 7 (8): 368–375. doi:10.1016/0022-4804(67)90080-7. ISSN0022-4804.
1969
Alican, Fikri; Hardy, James D. (1969). "A Description of the Course of Long-Term Survivors of Dog Liver Replantation". Surgical Forum. 20: 365–367. ISSN0071-8041. PMID4910609.
1970
Alican, Fikri (December 1970). "The Present Status of Lung Transplantation". Journal of the Tennessee Medical Association. 63 (12): 1011–1021. ISSN0040-3318. PMID5532334.
Turner, Manson Don; Alican, Fikri (January–February 1970). "Successful 20-Hour Storage of the Canine Liver by Continuous Hypothermic Perfusion". Cryobiology. 6 (4): 293–301. doi:10.1016/s0011-2240(70)80083-9. ISSN0011-2240. PMID4911453.
1971
Alican, Fikri; Hardy, James D.; Çayırlı, Mukadder; Varner, Joseph E.; Moynihan, Patricia C.; Turner, Manson Don; Anas, Pandeli (February 1971). "Intestinal Transplantation: Laboratory Experience and Report of a Clinical Case". The American Journal of Surgery. 121 (2): 150–159. doi:10.1016/0002-9610(71)90092-4. ISSN0002-9610. PMID5540665.
Alican, Fikri; Çayırlı, Mukadder; Keith, Virginia (March 1971). "One-Stage Hepatectomy in the Dog with Restoration of the Vena Cava by End-to-End Anastomosis". Surgery. 69 (3): 427–432. ISSN0039-6060. PMID5544895.
^ Alican's official record of birth, 2 April 1930, is off by one year, a relatively common practice at the time by Turkish families hoping to secure, through late declaration of male births, an extra year of growth for their sons prior to conscription (formally at age eighteen).
^ Biographical details are available in Alican's autobiography (2000/2007), cited below in the references and listed above among his publications.[1]
^ The world's first heart transplant into a human was performed by James D. Hardy at the University of Mississippi Medical Center on 23 January 1964. The heart was that of a chimpanzee. As further progress in the United States awaited the resolution of ethical and legal issues in organ transplantation, other countries picked up the pace, and Christiaan Barnard became the first to use a human heart for the procedure, performing the operation in his native South Africa on 3 December 1967.[4]
^ His autobiography places the duration at twenty-five years. That figure originates in the first edition (2000), never updated in the second edition (2007).[45] The preface to his Genel Cerrahi (2007) gives the current figure as "more than thirty years."[46]
^ The combined page count of Alican's medical monographs (close to 5,000 pages) actually exceeds his own estimate of 3,000 pages[47] by more than 60%, which shows that the total he reports is a net figure excluding the 2007 compilation in order to avoid redundancy.
^ Alican, in his autobiography, identifies this volume (1968) as his first book, adding that he failed to attract attention (from publishers) to it for eight years between its completion in 1960 and its eventual publication in 1968.[48] This suggests that the first two entries listed among his monographs in the corresponding section above may, especially since the two titles are almost identical, at least in meaning, actually refer to the same work, perhaps the first (1960) being a printed manuscript and the second (1960) a proper publication. As against this possibility, the autobiography (2007) comes with a picture of the cover page of the first book (1960), where a publisher is in fact listed, along with a book series and the number of the specific title in that series.[49]
^ Alican's preface to Genel Cerrahi (2007), appearing in both volumes, introduces the entirety of that work as a compilation of previously published monographs with minor emendations. His tally in the preface is eleven books, counting as separate works both of the two editions of his study on cancer (1993/1997) as well as each volume of his trilogy on surgery (1994–1995), all listed above in the section on his publications.[50]
References
^ abAlican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 271–293. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 312–313. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 312–313, 593–594. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 228, 316–318, 319–320, 347–348, 389. ISBN978-9-7542-0574-9.
^Hardy, James D. (1986). The World of Surgery, 1945–1985: Memoirs of One Participant. Philadelphia: University of Pennsylvania Press. p. 290. ISBN978-0-8122-8000-5.
^Alican, Fikri (December 1970). "The Present Status of Lung Transplantation". Journal of the Tennessee Medical Association. 63 (12): 1011–1021. ISSN0040-3318. PMID5532334.
^Alican, Fikri (1967). "Experimental Orthotopic Liver Transplantation: Experience with 150 Dogs". New Istanbul Contribution to Clinical Science. 9 (3): 71–98. ISSN0028-5447. PMID16300153.
^Alican, Fikri (April 1967). "Köpekte Total Hepatektomiden Sonra Karaciğerin Tekrar Yerine Takılması [Replantation of the Liver in Dogs Following Total Hepatectomy]". Türk Tıp Cemiyeti Mecmuası. 33 (4): 209–226. ISSN0494-2736. PMID4863470.
^Alican, Fikri (May 1967). "Eksperimantal Karaciğer Homotransplantasyonu [Experimental Liver Homotransplantation]". Türk Tıp Cemiyeti Mecmuası. 33 (5): 296–311. ISSN0494-2736.
^Alican, Fikri; Hardy, James D. (August 1967). "Replantation of the Liver in Dogs". The Journal of Surgical Research. 7 (8): 368–375. doi:10.1016/0022-4804(67)90080-7. ISSN0022-4804.
^Alican, Fikri; Hardy, James D. (1969). "A Description of the Course of Long-Term Survivors of Dog Liver Replantation". Surgical Forum. 20: 365–367. ISSN0071-8041. PMID4910609.
^Turner, Manson Don; Alican, Fikri (January–February 1970). "Successful 20-Hour Storage of the Canine Liver by Continuous Hypothermic Perfusion". Cryobiology. 6 (4): 293–301. doi:10.1016/s0011-2240(70)80083-9. ISSN0011-2240. PMID4911453.
^Alican, Fikri; Çayırlı, Mukadder; Keith, Virginia (March 1971). "One-Stage Hepatectomy in the Dog with Restoration of the Vena Cava by End-to-End Anastomosis". Surgery. 69 (3): 427–432. ISSN0039-6060. PMID5544895.
^Alican, Fikri; Hardy, James D.; Çayırlı, Mukadder; Varner, Joseph E.; Moynihan, Patricia C.; Turner, Manson Don; Anas, Pandeli (February 1971). "Intestinal Transplantation: Laboratory Experience and Report of a Clinical Case". The American Journal of Surgery. 121 (2): 150–159. doi:10.1016/0002-9610(71)90092-4. ISSN0002-9610. PMID5540665.
^Alican, Fikri; Hardy, James D. (1961). "Relationship and Significance of the Levels of Direct Bilirubin, Indirect Bilirubin, and Alkaline Phosphatase in Lymph, Blood, and Urine After Ligation of the Common Bile Duct". Surgical Forum. 12: 337–339. ISSN0071-8041. PMID13860424.
^Hardy, James D.; Alican, Fikri (July 1961). "Ischemic Gangrene without Major Organic Vascular Occlusion: An Enlarging Concept". Surgery. 50 (1): 107–114. ISSN0039-6060. PMID13711520.
^Alican, Fikri (March 1962). "A Sensitive Method for Recording Lymph Flow: Observations on the Dynamics of Hepatosplanchnic Blood and Lymph". The Journal of Surgical Research. 2 (2): 104–109. doi:10.1016/S0022-4804(62)80004-3. ISSN0022-4804. PMID13860425.
^Alican, Fikri; Hardy, James D. (August 1962). "Lymphatic Transport of Bile Pigments and Alkaline Phosphatase in Experimental Common Duct Obstruction". Surgery. 52 (2): 366–372. ISSN0039-6060. PMID13860422.
^Alican, Fikri (1968). Transplantasyon Biyolojisi: Hızla Gelişmekte Olan Yeni Bir Bilim [Transplantation Biology: A Rapidly Developing New Science]. Istanbul: İstanbul Üniversitesi Tıp Fakültesi.
^Alican, Fikri; Hardy, James D. (December 1961). "Mechanisms of Shock as Reflected in Studies of Lymph of Abdominal Organs". Surgery, Gynecology & Obstetrics. 113: 743–756. ISSN0039-6087. PMID13860423.
^Alican, Fikri (August 1962). "Pathophysiology of Endotoxin Shock: Clinical Observations and Experimental Studies". The American Journal of the Medical Sciences. 244 (2): 237–257. doi:10.1097/00000441-196208000-00014. ISSN0002-9629. PMID13860426.
^Alican, Fikri; Hardy, James D. (1962). "Sympatho-Adrenal System in Endotoxin Shock". Surgical Forum. 13: 8–10. ISSN0071-8041. PMID14012021.
^Alican, Fikri; Dalton, Jr., Martin L.; Hardy, James D. (June 1962). "Experimental Endotoxin Shock: Circulatory Changes with Emphasis upon Cardiac Function". The American Journal of Surgery. 103 (6): 702–708. doi:10.1016/0002-9610(62)90249-0. ISSN0002-9610. PMID13860421.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 493–496. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 385–390, 418–420. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 428–431, 457–458. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 492–493. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 573–576. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. p. 573. ISBN978-9-7542-0574-9. See pp. 574–575 for an itemized list of the twenty-two journals.
^Alican, Fikri (2007). Genel Cerrahi [General Surgery]. Vol. one. Istanbul: Nobel Tıp Kitabevleri. p. vi. ISBN978-9-7542-0532-9. Reprinted in volume two (pp. vi) ISBN978-9-7542-0533-6.
^ abAlican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. p. 576. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. pp. 288–290, 380. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007) [1st ed. 2000]. Koca Meşe'nin Gölgesi [The Shadow of the Grand Oak] (2nd ed.). Istanbul: Nobel Tıp Kitabevleri. p. 289. ISBN978-9-7542-0574-9.
^Alican, Fikri (2007). Genel Cerrahi [General Surgery]. Vol. one. Istanbul: Nobel Tıp Kitabevleri. pp. vi–vii. ISBN978-9-7542-0532-9. Reprinted in volume two (pp. vi-vii) ISBN978-9-7542-0533-6.
Gallery
Fikri Alican (age 26) in May 1955 at graduation from medical school (Istanbul University)
Fikri Alican (age 26) in May 1955 as a young doctor fresh out of medical school (Istanbul University)
Fikri Alican (age 31) in the summer of 1960 visiting his parents at their home
Fikri Alican (age 40) in July 1969 at a conference on organ transplantation in Madrid
Fikri Alican (age early 40s) in the early 1970s delivering a lecture at Istanbul University
Fikri Alican (age 76) in August 2005 at home
Fikri Alican (age 77) in August 2006 at home
Fikri Alican (age 77) in December 2006 at his office