Fetuin-B

FETUB
Identifiers
Aliases	FETUB, 16G2, Gugu, IRL685, fetuin B
External IDs	OMIM: 605954; MGI: 1890221; GeneCards: FETUB
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,653,141 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,758,528 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; testicle; ; skin of abdomen; ; skin of leg; ; oral cavity; ; mucosa of pharynx; ; human penis; ; vagina; ; rectum; ; metanephros;
	Top expressed in
	olfactory epithelium; ; esophagus; ; left lobe of liver; ; zygote; ; lip; ; secondary oocyte; ; primary oocyte; ; membranous bone; ; molar; ; Dermatocranium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; cysteine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; molecular function;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	negative regulation of peptidase activity; negative regulation of endopeptidase activity; single fertilization; binding of sperm to zona pellucida; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26998
	59083
	ENSG00000090512
	ENSMUSG00000022871
	Q9UGM5
	Q9QXC1
NM_001308077; NM_001308079; NM_014375; NM_001375587; NM_001375588;
	NM_001375589; NM_001375590; NM_001375591; NM_001375592
	NM_001083904; NM_001083905; NM_021564
NP_001295006; NP_001295008; NP_055190; NP_001362516; NP_001362517;
	NP_001362518; NP_001362519; NP_001362520; NP_001362521
	NP_001077373; NP_001077374; NP_067539
	Wikidata
View/Edit Human	View/Edit Mouse

Fetuin-B is a protein that in humans is encoded by the FETUB gene.^[5]^[6]

The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090512 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022871 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP (Jan 2001). "Fetuin-B, a second member of the fetuin family in mammals". Biochem J. 350 Pt 2 (2): 589–97. doi:10.1042/0264-6021:3500589. PMC 1221288. PMID 10947975.
^ ^a ^b "Entrez Gene: FETUB fetuin B".

Haidar M, Seddiki N, Gluckman JC, Gattegno L (1993). "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1". Glycoconj. J. 9 (6): 315–23. doi:10.1007/BF00731092. PMID 1284814. S2CID 7976435.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Denecke B, Gräber S, Schäfer C, et al. (2003). "Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A". Biochem. J. 376 (Pt 1): 135–45. doi:10.1042/BJ20030676. PMC 1223762. PMID 12943536.
Wajih N, Borras T, Xue W, et al. (2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin". J. Biol. Chem. 279 (41): 43052–60. doi:10.1074/jbc.M407180200. PMID 15280384.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hsu SJ, Nagase H, Balmain A (2005). "Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity". Genome. 47 (5): 931–46. doi:10.1139/g04-043. PMID 15499407.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Coen G, Ballanti P, Balducci A, et al. (2006). "Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry". Am. J. Kidney Dis. 48 (1): 106–13. doi:10.1053/j.ajkd.2006.03.083. PMID 16797392.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000090512 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022871 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10947975-5] Olivier E, Soury E, Ruminy P, Husson A, Parmentier F, Daveau M, Salier JP (Jan 2001). "Fetuin-B, a second member of the fetuin family in mammals". Biochem J. 350 Pt 2 (2): 589–97. doi:10.1042/0264-6021:3500589. PMC 1221288. PMID 10947975.

[entrez-6] "Entrez Gene: FETUB fetuin B".

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[5]

[6]

Fetuin-B

See also

References

Further reading

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