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Feline vaccination is animal vaccination applied to cats. Vaccination plays a vital role in protecting cats from infectious diseases, some of which are potentially fatal. They can be exposed to these diseases from their environment, other pets, or even humans.

Principles guiding vaccination recommendations

The practice of recommending and giving vaccines on a fixed schedule with annual boosters has been widely discarded. Current recommendations are based on the philosophy of vaccinating each cat no more frequently than necessary. These recommendations take into account considerations for the efficacy and duration of immunity (DOI)^[1] of available vaccines; environmental risks and likelihood of exposure; the specific needs and risks associated with age and overall health status of different cats and cat populations; and socioeconomic limitations.^[2]^[3]^[4]^[5]

Recommendation vary for:

Shelters
Owned pets (and based on "inside only", "in and out", or "out only")
Breeders
Boarding facilities (or animals going into them)
Feral cats
- Community cats
- TNR (trap–neuter–return) program

Specific consideration may be required for:

Travel plans
Underlying disease conditions of the specific cat
Pregnant or lactating/nursing cats
Multi-cat households or kitten foster homes

Core vs non-core vaccines

Core vaccines are ones that are considered "essential for health" and are recommended for both indoor and outdoor owned domestic cats, as well as community and feral cats. These include:

Feline panleukopenia (FPV or FPLV, aka feline parvo or feline distemper)
Feline viral rhinotracheitis (FHV, aka herpes virus)
Feline calicivirus (FCV)
Rabies (where the disease is endemic or required by law)

Non-core vaccines are recommended only for cats at risk of specific infection. These include:

Schedules for vaccinations

National, international, and global vaccination guidelines by professional veterinary advisory boards are regularly updated and available for on-line viewing or download. These include:

These guides provide recommendations for kittens and adult cats. They include initial requirements to establish adequate levels of acquired immunity, along with renewal (booster) recommendations to retain it. For some infectious diseases, blood samples can be used to measure antibody levels (titers) to determine DOI.^[1] Though these tests do not provide evidence of protective immunity, some clinicians use high titer results as an indicator, along with low disease exposure risk that vaccines might be administered at a longer than usual revaccination interval.^[6]

Types of vaccines

Numerous types and brands of commercial vaccines are available to induce acquired immunity. These include:

Modified-live virus (MLV or "infectious") non adjuvated
MLV adjuvated
Killed virus ("non-infectious") adjuvated
Killed virus non adjuvated.

Combination vaccines that provide protection against several common viruses are also available.

Selection or use of a specific type/brand of vaccine may vary depending on the overall risk of viral infection to the specific animal in its environment, along with considerations for the time it takes to confer protection, its overall efficacy, the animal's health, and the potential risks associated with MLV vs killed, adjuvated vs non adjuvated, intranasal/ocular vs injection.

Administration of vaccines

The laws as to who may acquire and give vaccines varies in different countries. Some may only be acquired and given by a licensed veterinarian, others by owners or caretakers.

The vaccine delivery method/route may vary. They may be given by injection, dermal application, or nasal/ocular application. Injection routes may be intra-muscular (IM) or subcutaneous (SQ). The specific injection site may vary depending on the type of vaccine (MLV vs killed) being given.

Reactions to vaccines

Vaccines must undergo safety trials to receive licensing and are considered very safe. A very small percentage of animals may have an adverse reaction. All advisory boards mentioned above strongly endorse the view that the benefits far outweigh the risks of not vaccinating an animal.^{[citation needed]}

Normal reactions

After vaccinations are administered, cats may experience mild and short-lived reactions such as poor appetite, lethargy, and fever. Any symptoms that persist for more than a day or two should be discussed with a veterinarian.^[7] Sometimes, for injected vaccines, a small, non-painful lump may form at the site where the vaccine was injected which usually disappears within four weeks.^[6]

Adverse (abnormal) reactions

Adverse events include any injury caused by the vaccine.^[2]

Rarely, a cat will have an allergic reaction to a vaccine. This may include facial itchiness, or be a generalized allergic reaction that includes vomiting, diarrhea, breathing difficulties, and extremely rarely, collapse. Should any of these occur, contact your veterinarian immediately. Anaphylactic reactions are rarely fatal if treated in a timely fashion. If an allergic reaction occurs, future vaccinations may be amended by type or preceded by an allergy medicine.^[7]

Another uncommon reaction is the development of a vaccine-associated fibrosarcoma, a tumor at the injection site that develops months or years after vaccination.^[7]

Adverse events should be reported, whether their association with vaccination is recognized or only suspected. Veterinarians are encouraged to report any clinically significant adverse event occurring during or after administration of any licensed vaccine.^[2] The report, identifying the product, batch, animal and reaction involved, should be submitted to the manufacturer of the vaccine and to the appropriate regulatory agency.