FRAT1

FRAT1
Identifiers
Aliases	FRAT1, WNT signaling pathway regulator, FRAT regulator of WNT signaling pathway 1
External IDs	OMIM: 602503; MGI: 109450; GeneCards: FRAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,321,915 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,821,022 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; testicle; ; granulocyte; ; pancreatic ductal cell; ; secondary oocyte; ; gonad; ; right lobe of liver; ; bone marrow; ; spleen;
	Top expressed in
	spermatid; ; granulocyte; ; muscle of thigh; ; neural layer of retina; ; embryo; ; spermatocyte; ; morula; ; duodenum; ; CA3 field; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; intracellular membrane-bounded organelle; cytoplasm;
Biological process	Wnt signaling pathway; beta-catenin destruction complex disassembly; canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10023
	14296
	ENSG00000165879
	ENSMUSG00000067199
	Q92837
	P70339
	NM_181355; NM_005479
	NM_008043
	NP_005470
	NP_032069
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.^[5]^[6]

The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165879 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067199 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMC 1169648. PMID 9034327.
^ ^a ^b "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas".

Li L, Yuan H, Weaver CD, et al. (1999). "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1". EMBO J. 18 (15): 4233–40. doi:10.1093/emboj/18.15.4233. PMC 1171499. PMID 10428961.
Saitoh T, Katoh M (2001). "FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer". Int. J. Oncol. 19 (2): 311–5. doi:10.3892/ijo.19.2.311. PMID 11445844.
Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation". Structure. 9 (12): 1143–52. doi:10.1016/S0969-2126(01)00679-7. PMID 11738041.
Saitoh T, Mine T, Katoh M (2002). "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer". Int. J. Oncol. 20 (4): 785–9. doi:10.3892/ijo.20.4.785. PMID 11894125.
Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2". Gene. 291 (1–2): 17–27. doi:10.1016/S0378-1119(02)00594-2. PMID 12095675.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hino S, Michiue T, Asashima M, Kikuchi A (2003). "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin". J. Biol. Chem. 278 (16): 14066–73. doi:10.1074/jbc.M213265200. PMID 12556519.
Khambata-Ford S, Liu Y, Gleason C, et al. (2003). "Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay". Genome Res. 13 (7): 1765–74. doi:10.1101/gr.529803. PMC 403750. PMID 12805274.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang Y, Hewitt SM, Liu S, et al. (2006). "Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours". Br. J. Cancer. 94 (5): 686–91. doi:10.1038/sj.bjc.6602988. PMC 2361213. PMID 16479254.
Hagen T, Cross DA, Culbert AA, et al. (2007). "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." J. Biol. Chem. 281 (46): 35021–9. doi:10.1074/jbc.M607003200. PMID 16982607.

External links

FRAT1 human gene location in the UCSC Genome Browser.
FRAT1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165879 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067199 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9034327-5] Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMC 1169648. PMID 9034327.

[entrez-6] "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas".

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FRAT1

References

Further reading

External links

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