Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene. FOXO3 belongs to the O subclass of the forkhead family of...

animals showed significant increase in the phosphorylation of Akt, eNOS, and FOXO3a. In addition, tyrosol also induced the expression of the protein SIRT1 in...

FOXO3a also acts as a tumor suppressor in nephroblastoma by inhibiting proliferation and invasion while inducing apoptosis. In breast cancer, FOXO3a suppresses...

inherited genes are believed to play an important role. A variation in the gene FOXO3A is known to have a positive effect on the life expectancy of humans, and...

(bDMARDs). The next one is the FOXO3A gene region been reported as associated with the worst disorder. The minor allele at FOXO3A summons a differential response...

244-498 (of 766aa) H3K9ac, H1K26ac, H4K16ac Hif-1α, HIF-2α, MYC, P53, BRCA1, FOXO3A, MyoD, Ku70, PPARγ, PCAF, Suv39h1, TGFB1, WRN, NBS1 Neurodegenerative diseases...

"Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation...

mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway". Biochemical and Biophysical Research Communications. 455...

produces an increase in lifespan for worms, flies, mice; similar variants of FOXO3a have been associated with longer human lives as well. FOXO4 can bind with...

proteasome degradation. DYRK1A, DYRK1B, protein kinase B, eEF2, IKK2, p53, FOXO3A, CEP192 are also reportedly hydroxylated by PHD1. p53 and MAPH6 are also...

BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, et al. (September 2008). "FOXO3A genotype is strongly associated with human longevity". Proceedings of the...

allosteric activator of SIRT3 alleviates diabetic kidney disease via the SIRT3-Foxo3a signaling axis". Free Radical Biology & Medicine. 240: 29–45. doi:10.1016/j...

PPI3K/AKT/IKK. Drugs such as Paclitaxel, Imatinib, and doxorubicin which activate FoxO3a or its targets are being used. Modification to modulate related factors...

Kimberly A. (2013-02-06). "Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects"...

damage and mitochondria-mediated apoptosis through activation of the SIRT3/FOXO3a signaling pathway in neurocytes". Food & Function. 11 (3): 2535–2542. doi:10...

PTPN11/Shp2, PLCγ, PI3K, and NF1. Other reported downstream ALK targets include FOXO3a, CDKN1B(p27Kip1), cyclin D2, NIPA, RAC1, CDC42, BCAR1(p130Cas), SHP1, and...

BRCA1 CREB Cubitus interruptus (in D. melanogaster) ELK4 (SAP1) FOXO3 (FOXO3a) GLI3 JUN (c-Jun) KMT2A (MLL) MYB (c-Myb) NFE2 (NF-E2 p45) RELA (NF-κB p65)...

response element (FHRE) consensus sequence for FOXO3a in the human, mouse and rat Mmp13 promoter. Endogenous FOXO3a activation results in marked upregulation...

β-hydroxybutyrate (BHB) has been shown in mice to increase gene expression of FOXO3a by histone deacetylase inhibition. Histone deacetylase inhibitors may modulate...

protein-kinase (AMPK) and the expression of the Forkhead transcription factor, FOXO3a, in adipose tissue. Obese rats showed significant increases in weight gain...

Schreibera, Stefan; Nebela, Almut (February 24, 2009). "Association of FOXO3A variation with human longevity confirmed in German centenarians". Proceedings...

deacetylating PGC-1α, upregulates antioxidant enzyme expression by deacetylating FOXO3a, and thereby reduces ROS levels. Also, Sirt2 can reactivate the inactive...

"RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells". Signal Transduction and Targeted Therapy...

in adulthood, resulting in a POF phenotype. Foxo3a - Studies into mice with complete and partial Foxo3a deletions also showed premature activation of...

Ballestas ME, Roth KA (2012-06-28). "CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER...

Blázquez-Domingo M, Kolbus A, Besooyen J, Steinlein P, Beug H, et al. (January 2004). "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein...

factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis...

M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M, et al. (July 2006). "FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal"...

nuclear localization of the autophagy-related transcription factors FOXO3/FOXO3A and TFEB, suggesting that DIRAS1, along with DIRAS2, may behave as a surrogates...

Kim JY, Park KW, Koo BK, et al. (2007). "Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading...

downregulates POLD1 indirectly by suppressing the transcription factor FOXO3a, which has putative binding sites in the POLD1 promoter (RTMAAYA; response...

Mao ZB (2010). "Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively...