FBXO28

FBXO28
Identifiers
Aliases	FBXO28, CENP-30, Fbx28, F-box protein 28, DEE100
External IDs	OMIM: 609100; MGI: 1261890; GeneCards: FBXO28
Gene location (Human)
Chr.	Chromosome 1 (human)
End	224,162,047 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	182,169,194 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; skin of thigh; ; Epithelium of choroid plexus; ; skin of hip; ; endothelial cell; ; kidney tubule; ; Achilles tendon; ; Brodmann area 23; ; tibia; ; germinal epithelium;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; external carotid artery; ; internal carotid artery; ; lacrimal gland; ; submandibular gland; ; motor neuron; ; parotid gland; ; retinal pigment epithelium;
	More reference expression data
	; ;
	More reference expression data
Orthologs
Databases	NCBI: entry; OMA: entry
	23219
	67948
	ENSG00000143756
	ENSMUSG00000047539
	Q9NVF7
	Q8BIG4
	NM_001136115; NM_015176
	NM_175127
	NP_001129587; NP_055991
	NP_780336
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene.^[5]^[6]

Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143756 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047539 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
^ ^a ^b "Entrez Gene: FBXO28 F-box protein 28".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143756 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047539 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9455484-5] Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.

[entrez-6] "Entrez Gene: FBXO28 F-box protein 28".

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FBXO28

References

Further reading

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