FAM241B
219738
| FAM241B | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | FAM241B, C10orf35, chromosome 10 open reading frame 35, family with sequence similarity 241 member B | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1917144; GeneCards: FAM241B | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein FAM241B is a protein that in humans is encoded by the gene FAM241B (previously C10orf35).[5] Not much is reported about the protein, but it is predicted to be a transmembrane protein.[5] The protein contains the domain of unknown function 4605 (DUF4605)[5] which belongs to the protein family pfam15378.[6]
General characteristics
The physical properties of the c10orf35 protein were analyzed, and the molecular weight was predicted to be 13.2 kdal,[7] and the isoelectric point was predicted to be 11.5.[7] The properties of DUF4605 were also analyzed, and the molecular weight was predicted to be 6.0 kdal.[7] The isoelectric point was predicted to be 6.9,[7] which is significantly less basic than the full protein.
Properties and structure
DUF 4605 is located between amino acids 62 and 92.[5] The secondary structure of the c10orf35 protein was predicted to consist of a β-sheet between amino acids 3 and 5, an α-helix between 61 and 72, and a transmembrane α-helix between 92 and 112.[8] The serine in position 62 can be phosphorylated to form a phosphoserine group.[8]
Expression
The c10orf35 protein has expression over the 75th percentile in the brain, spinal cord, and male reproductive organs.[10] Within the male reproductive system, the RNA is found within the testis and prostate, while the protein is expressed in the epididymis.[11] In the brain, the RNA is found in the cerebral cortex, while the protein is expressed ubiquitously throughout the brain.[11]
Protein interactions
The c10orf35 protein has been experimentally shown by Affinity Capture-MS to interact with 7 other proteins[5] as shown below.
| Interacting Protein Symbol | Definition |
|---|---|
| ATP1B3 | ATPase, Na+/K+ Transporting, Beta 3 Polypeptide |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) |
| GABRE | Gamma-aminobutyric acid (GABA) A receptor, epsilon |
| HTR3C | 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic |
| LPAR1 | Lysophosphatidic acid receptor 1 |
| SGCD | Sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) |
| ZACN | Zinc activated ligand-gated ion channel |
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171224 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020083 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c d e "c10orf35". National Center For Biotechnology Information (NCBI) Gene.
- ^ "Conserved Protein Domain Family DUF4605". National Center For Biotechnology Information (NCBI) Structure. Retrieved 6 May 2016.
- ^ a b c d "Compute pI/Mw". ExPASy Bioinformatics Research Portal. Retrieved 6 May 2016.
- ^ a b "c10orf35". UniProt. Retrieved 9 May 2016.
- ^ "Gene Expression Omnibus (GEO) Profile For GDS3834". National Center For Biotechnology Information (NCBI). Retrieved 9 May 2016.
- ^ "Gene Expression Omnibus (GEO) Profile". National Center For Biotechnology Information. Retrieved 6 May 2016.
- ^ a b "c10orf35". The Human Protein Atlas. Retrieved 6 May 2016.
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