In his nineteen-year career as a football defender, which lasted from 1924 to 1943, he played for Casale, Bologna, and Roma. With Bologna, he was victorious in the 1928–29 championship, also winning two Mitropa Cups in 1932 and 1934.[3][4]
Despite his success and fame as a footballer, following the conclusion of the Second World War, however, Monzeglio had initially attracted controversy, due to his political views and close friendship with the Italian fascist dictator Benito Mussolini, as well as his role as Mussolini's personal coach.[7][8] Monzeglio later became a coach, managing the Italian teams of A.S. Roma, Como, Pro Sesto, Napoli, Sampdoria, Juventus, and Lecco, as well as Chiasso, in Switzerland, between 1941 and 1973. Monzeglio died in Turin, on 3 November 1981, at the age of 75.[3] In 2013, he was posthumously inducted into the Italian Football Hall of Fame.[9]