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Partner
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Profil Sekolah - Kampus
Dokumen 123
Englitazone
Chemical compound
Englitazone
Clinical data
ATC code
none
Identifiers
IUPAC name
5-[(2-Benzyl-3,4-dihydro-2
H
-chromen-6-yl)methyl]-1,3-thiazolidine-2,4-dione
CAS Number
109229-58-5
PubChem
CID
60303
ChemSpider
54375
UNII
ZQW5577C3O
ChEMBL
ChEMBL17669
CompTox Dashboard
(
EPA
)
DTXSID80883191
Chemical and physical data
Formula
C
20
H
19
N
O
3
S
Molar mass
353.44
g·mol
−1
3D model (
JSmol
)
Interactive image
SMILES
O=C1NC(=O)SC1Cc4ccc3OC(Cc2ccccc2)CCc3c4
Englitazone
is a
hypoglycemic
agent of
thiazolidinedione
(
glitazone
) class.
See also
Ciglitazone
Darglitazone
Netoglitazone
Troglitazone
Rivoglitazone
—currently in clinical trials
Pioglitazone
,
lobeglitazone
,
rosiglitazone
—the only ones currently in clinical use
References
v
t
e
Oral
diabetes medication
,
insulins
and
insulin analogs
, and other drugs used in diabetes (
A10
)
Insulins
/
insulin analogs
fast-acting
Insulin aspart
Insulin glulisine
Insulin lispro
short-acting
Regular insulin
#
long-acting
Insulin detemir
#
Insulin glargine
#
(
+lixisenatide
)
NPH insulin
Lente insulin
‡
Ultralente insulin
‡
ultra-long-acting
Insulin degludec
#
(
+insulin aspart
,
+liraglutide
)
Insulin icodec
†
(
+semaglutide
)
inhalable
Exubera
‡
Afrezza
#
WHO-EM
‡
Withdrawn
from market
Clinical trials
:
†
Phase III
§
Never to phase III
Non-insulins
Insulin sensitizers
Biguanides
Buformin
‡
Metformin
#
Phenformin
‡
TZDs
/"glitazones" (
PPAR
)
Ciglitazone
§
Darglitazone
§
Englitazone
§
Lobeglitazone
Netoglitazone
§
Pioglitazone
Rivoglitazone
†
Rosiglitazone
Troglitazone
‡
Dual PPAR agonists
Aleglitazar
†
Muraglitazar
§
Saroglitazar
Tesaglitazar
§
Amylin
analogs and
DACRAs
Cagrilintide
§
Pramlintide
Secretagogues
K
+
ATP
Sulfonylureas
1st generation
:
Acetohexamide
Carbutamide
Chlorpropamide
Glycyclamide
Metahexamide
Tolazamide
Tolbutamide
2nd generation
:
Glibenclamide (glyburide)
Glibornuride
Glicaramide
Gliclazide
#
Glimepiride
Glipizide
Gliquidone
Glisoxepide
Glyclopyramide
Meglitinides
/"glinides"
Mitiglinide
Nateglinide
Repaglinide
GLP-1 receptor agonists
Albiglutide
‡
Danuglipron
†
Dulaglutide
Exenatide
Liraglutide
Lixisenatide
Orforglipron
§
Semaglutide
Taspoglutide
†
GLP1 poly-agonist peptides
Mazdutide
(GLP-1/
GCGR
)
Retatrutide
§
(GLP-1/GIP/GCGR)
Tirzepatide
(GLP-1/GIP)
DPP-4 inhibitors
/"gliptins"
Alogliptin
Anagliptin
Evogliptin
Garvagliptin
Gemigliptin
Gosogliptin
Linagliptin
Melogliptin
Omarigliptin
Saxagliptin
Sitagliptin
Teneligliptin
Trelagliptin
Vildagliptin
Other
Aldose reductase inhibitors
Epalrestat
Fidarestat
§
Ranirestat
†
Tolrestat
‡
Zenarestat
§
Alpha-glucosidase inhibitors
Acarbose
Miglitol
Voglibose
SGLT2 inhibitors
/"gliflozins"
Canagliflozin
Dapagliflozin
Empagliflozin
#
Ertugliflozin
Ipragliflozin
Luseogliflozin
Remogliflozin
§
Sergliflozin
§
Sotagliflozin
Tofogliflozin
†
Velagliflozin
Other
Benfluorex
‡
Bromocriptine
Imeglimin
Combinations
Alogliptin/metformin
Canagliflozin/metformin
Cagrilintide/semaglutide
§
Dapagliflozin/metformin
Dapagliflozin/saxagliptin
Dapagliflozin/saxagliptin/metformin
Empagliflozin/linagliptin
Empagliflozin/metformin
Gemigliptin/rosuvastatin
Glibenclamide (glyburide)/metformin
Glimepiride/rosiglitazone
Linagliptin/metformin
Metformin/acarbose
Metformin/ertugliflozin
Metformin/evogliptin
Metformin/gemigliptin
Metformin/repaglinide
Metformin/sulfonylureas
Metformin/teneligliptin
Phenformin/sulfonylureas
Pioglitazone/alogliptin
Pioglitazone/glimepiride
Pioglitazone/metformin
Pioglitazone/sitagliptin
Rosiglitazone/metformin
Saxagliptin/metformin
Sitagliptin/dapagliflozin
Sitagliptin/ertugliflozin
Sitagliptin/metformin
Sitagliptin/simvastatin
Vildagliptin/metformin
#
WHO-EM
‡
Withdrawn
from market
Clinical trials
:
†
Phase III
§
Never to phase III
v
t
e
PPAR
Tooltip Peroxisome proliferator-activated receptor
modulators
PPARα
Tooltip Peroxisome proliferator-activated receptor alpha
Agonists:
15-HETE
15-HpETE
Aleglitazar
Aluminium clofibrate
Arachidonic acid
Bezafibrate
Chiglitazar
Clofibrate
CP-775146
Daidzein
DHEA
(
prasterone
) (in rodents)
Elafibranor
Etomoxir
Fenofibrate
Genistein
Gemfibrozil
GW-7647
Lanifibranor
Leukotriene B
4
LG-101506
LG-100754
Lobeglitazone
Muraglitazar
Oleylethanolamide
Palmitoylethanolamide
Pemafibrate
Perfluorononanoic acid
Perfluorooctanoic acid
Pioglitazone
Saroglitazar
Sodelglitazar
Tesaglitazar
Tetradecylthioacetic acid
Troglitazone
WY-14643
Antagonists:
GW-6471
MK-886
PPARδ
Tooltip Peroxisome proliferator-activated receptor delta
Agonists:
15-HETE
15-HpETE
Arachidonic acid
Bezafibrate
Daidzein
Elafibranor
Fonadelpar
Genistein
GW-0742
GW-501516
L-165,041
Lanifibranor
LG-101506
Seladelpar
Sodelglitazar
Tetradecylthioacetic acid
Antagonists:
FH-535
GSK-0660
GSK-3787
PPARγ
Tooltip Peroxisome proliferator-activated receptor gamma
Agonists:
5-Oxo-ETE
5-Oxo-15-hydroxy-ETE
15-Deoxy-Δ
12,14
-prostaglandin J
2
15-HETE
15-HpETE
Aleglitazar
Arachidonic acid
Balaglitazone
Berberine
Bezafibrate
Cannabidiol
Cevoglitazar
Chiglitazar
Ciglitazone
Daidzein
Darglitazone
Edaglitazone
Efatutazone
Englitazone
Etalocib
Farglitazar
Genistein
GW-1929
Ibuprofen
Imiglitazar
Indeglitazar
Lanifibranor
LG-100268
LG-100754
LG-101506
Lobeglitazone
Muraglitazar (muroglitazar)
nTZDpa
Naveglitazar
Netoglitazone
Oxeglitazar
Peliglitazar
Pemaglitazar
Perfluorononanoic acid
Pioglitazone
Prostaglandin J
2
Ragaglitazar
Reglitazar
Rivoglitazone
Rosiglitazone
RS5444
Saroglitazar
Sipoglitazar
Sodelglitazar
Telmisartan
Tesaglitazar
Troglitazone
SPPARMs
Tooltip Selective PPARγ modulator
:
BADGE
EPI-001
INT-131
MK-0533
S26948
Antagonists:
FH-535
GW-9662
SR-202
T-0070907
Unknown:
SR-1664
Non-selective
Agonists:
Ciprofibrate
Clinofibrate
Clofibride
Englitazone
Etofibrate
Farglitazar
Netoglitazone
Ronifibrate
Rivoglitazone
Simfibrate
See also
Receptor/signaling modulators