Isis was created in the 1931 redistribution under the Moore government, replacing the former district of Burrum. It primarily comprised the area between Bundaberg and Maryborough, not including the cities themselves.
Isis was primarily a safe seat for the Country party. PremierJack Pizzey was the member for Isis from 1950 until his sudden death in 1968. The seat was then won by Labor in the resulting by-election.
Isis was abolished in the 1991 redistribution under the Goss government, being replaced by the new district of Hervey Bay.