He played professionally in the National Football League (NFL) with the Green Bay Packers in 1962 and Philadelphia Eagles from 1963 to 1966. He was named All-Pro after the 1964 NFL season. Blaine was inducted into the Missouri Sports Hall of Fame on September 29, 2011.
Later years
Blaine is the former Dalton Cardiovascular Research Center Director and continues as a Dalton Development officer and Investigator and Professor in the Department of Medical Pharmacology and Physiology with the University of Missouri. Dr. Ed Blaine was not only successful on the football field but also as one of the nation's foremost pharmaceutical researchers with an interest in hypertension and heart failure.
In November 2009, Dr. Blaine was also recognized as a Distinguished Eagle Scout by the Boy Scouts of America. This recognition is held with other greats such as astronaut Neil Armstrong, former President Gerald Ford, and Secretary of Defense Robert Gates.