ERLIN2

ERLIN2
Identifiers
Aliases	ERLIN2, C8orf2, Erlin-2, NET32, SPFH2, SPG18, ER lipid raft associated 2
External IDs	OMIM: 611605; MGI: 2387215; GeneCards: ERLIN2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,758,422 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,530,356 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; renal medulla; ; Achilles tendon; ; islet of Langerhans; ; parotid gland; ; germinal epithelium; ; mucosa of paranasal sinus; ; bronchial epithelial cell; ; kidney tubule; ; caput epididymis;
	Top expressed in
	spermatocyte; ; otolith organ; ; utricle; ; Epithelium of choroid plexus; ; right kidney; ; vestibular membrane of cochlear duct; ; decidua; ; superior cervical ganglion; ; gastrula; ; proximal tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; protein binding; protein tyrosine kinase activity; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; membrane raft; membrane; endoplasmic reticulum; plasma membrane; endoplasmic reticulum membrane; cytosol; protein-containing complex;
Biological process	SREBP signaling pathway; steroid metabolic process; cholesterol metabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; lipid metabolism; ubiquitin-dependent ERAD pathway; peptidyl-tyrosine phosphorylation; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11160
	244373
	ENSG00000147475
	ENSMUSG00000031483
	O94905
	Q8BFZ9
	NM_001003790; NM_001003791; NM_007175; NM_001362878; NM_001362880
NM_153592; NM_001364476; NM_001364477; NM_001379175; NM_001379176;
	NM_001379177; NM_001379178
	NP_001003790; NP_001003791; NP_009106; NP_001349807; NP_001349809
NP_705820; NP_001351405; NP_001351406; NP_001366104; NP_001366105;
	NP_001366106; NP_001366107; NP_001391043; NP_001391044; NP_001391045
	Wikidata
View/Edit Human	View/Edit Mouse

Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147475 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenetics and Cell Genetics. 85 (3–4): 227–31. doi:10.1159/000015298. PMID 10449903. S2CID 39559998.
^ Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes". Oncogene. 24 (33): 5235–45. doi:10.1038/sj.onc.1208741. PMID 15897872.
^ Browman DT, Resek ME, Zajchowski LD, Robbins SM (Aug 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". Journal of Cell Science. 119 (Pt 15): 3149–60. doi:10.1242/jcs.03060. PMID 16835267.
^ "Entrez Gene: ERLIN2 ER lipid raft associated 2".

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Pearce MM, Wang Y, Kelley GG, Wojcikiewicz RJ (Jul 2007). "SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells". The Journal of Biological Chemistry. 282 (28): 20104–15. doi:10.1074/jbc.M701862200. PMID 17502376.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147475 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10449903-5] Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenetics and Cell Genetics. 85 (3–4): 227–31. doi:10.1159/000015298. PMID 10449903. S2CID 39559998.

[pmid15897872-6] Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes". Oncogene. 24 (33): 5235–45. doi:10.1038/sj.onc.1208741. PMID 15897872.

[pmid16835267-7] Browman DT, Resek ME, Zajchowski LD, Robbins SM (Aug 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". Journal of Cell Science. 119 (Pt 15): 3149–60. doi:10.1242/jcs.03060. PMID 16835267.

[entrez-8] "Entrez Gene: ERLIN2 ER lipid raft associated 2".

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ERLIN2

References

Further reading

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