Draft:Scott Tenenbaum

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Draft:Scott Tenenbaum
  • Comment: This tells us everything your boss would like us to know about him, see WP:BOSS. Theroadislong (talk) 13:30, 16 August 2026 (UTC)
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Scott Allen Tenenbaum
Scott Tenenbaum
BornDecember 23, 1964[citation needed]
St. Louis, Missouri, U.S.[citation needed]
EducationLadue High School[citation needed]
University of Missouri (B.A., 1986)
Wright State University
Tulane University (Ph.D., 1994)
OccupationsMicrobiologist, nanobioscientist, academic researcher
Employer(s)University at Albany, SUNY
Known forRibonomics; RIP, RIP-Chip, and RIP-Seq technologies; structurally interacting RNA (sxRNA)
SpouseDr. Diane (Cantor) Tenenbaum[1][2]
Children3 (Max, Zachary, Samuel)[1][2]
Websitewww.albany.edu/nanoscale-science-engineering/faculty/scott-tenenbaum

Scott Allen Tenenbaum (born December 23, 1964[citation needed]) is an American microbiologist, nanobioscientist, and academic researcher whose work focuses on RNA biology, post-transcriptional gene regulation, RNA-binding proteins, and RNA nanotechnology. He is Director of RNA Nanotechnology and an associate professor of nanobioscience at the College of Nanotechnology, Science and Engineering, University at Albany, State University of New York (SUNY).[3][4] His research has contributed to the development of ribonomics, RNA immunoprecipitation technologies (RIP, RIP-Chip, and RIP-Seq), and structurally interacting RNA (sxRNA), an RNA-based platform for molecular tools, diagnostics, and therapeutic applications.[3]

Tenenbaum has led federally funded research supported by the National Institutes of Health (NIH) and National Science Foundation (NSF), maintaining continuous NIH funding for over 20 years.[3] He was among the early participants in the NIH/NHGRI Encyclopedia of DNA Elements (ENCODE) Consortium, where his laboratory adapted RNA immunoprecipitation techniques for next-generation sequencing (RIP-Seq) to study RNA–protein interactions.[3][5] He is also the founder and CEO of sxRNA Technologies, Inc.[6][7]

Early life and education

Tenenbaum was born and raised in St. Louis, Missouri, and attended Ladue High School.[citation needed] He studied biology at the University of Michigan, Ann Arbor (1982–1984), before transferring to the University of Missouri, Columbia, where he earned a Bachelor of Arts in Biology in 1986.[6] He subsequently studied microbiology and immunology at Wright State University, Dayton, Ohio (1987–1989), researching interferon antiviral immunomodulation under Nancy Bigley.[6]

He earned a Ph.D. in Microbiology and Immunology from Tulane University Medical Center in 1994, where his doctoral research under Robert F. Garry examined viral–host interactions and autoimmune disease mechanisms.[6][3] It was at Tulane that he met his future wife, Diane Cantor.[8]

From 1994 to 1997, he completed a postdoctoral fellowship in Hematology/Oncology at Tulane University Medical Center as a National Hemophilia Foundation Judith Graham Pool Fellow, studying HIV resistance in severe hemophiliacs under Cynthia A. Leissinger.[6] He then joined Duke University Medical Center (1997–2003) as a postdoctoral fellow in the Department of Molecular Genetics and Microbiology under Jack D. Keene, studying RNA-binding proteins and post-transcriptional gene regulation.[6][3]

Career

Tenenbaum remained at Duke University Medical Center as a Senior Research Associate (2000–2003) before joining the University at Albany in 2003 as an Assistant Professor in the Department of Biomedical Sciences.[3]

In 2009, he became Associate Professor of Nanobioscience and Associate Head of the Nanobioscience Constellation at the College of Nanoscale Science and Engineering, University at Albany, and served as Acting Vice President for Research at the college during 2009–2011.[6][3]

He served as Head of Nanobioscience at the College of Nanoscale Science and Engineering (2009–2024, first at UAlbany-SUNY and later at SUNY Polytechnic Institute), and became Director of RNA Nanotechnology in 2014, a position he continues to hold.[6][3] In 2025, he was named Director of Graduate Studies for the Department of Nanoscience and Engineering.[6] He is also affiliated with The RNA Institute at the University at Albany.[9]

Research

Tenenbaum's research addresses mechanisms of post-transcriptional gene regulation, RNA-binding proteins, RNA–protein interactions, and RNA structure, combining experimental and computational approaches across molecular biology, genomics, and nanotechnology.[3]

Ribonomics and post-transcriptional gene regulation

During his postdoctoral work at Duke with Jack D. Keene, Tenenbaum helped develop experimental approaches for identifying messenger RNA subsets associated with ribonucleoprotein complexes, contributing to the field later known as ribonomics.[10] This work contributed to the post-transcriptional operon hypothesis, a term Tenenbaum has stated he first proposed together with the "USER code" concept while working with Keene.[11] The impact of the post-transcriptional operon hypothesis on the field has been discussed in subsequent review literature.[12]

RNA immunoprecipitation technologies

Tenenbaum's laboratory helped establish and refine RNA immunoprecipitation (RIP)-based methods, including RIP-Chip (microarray-based) and later RIP-Seq (sequencing-based), for characterizing RNA–protein interaction networks on a genomic scale.[13][14]

ENCODE Consortium

Tenenbaum was a member of the NIH/NHGRI ENCODE Consortium from 2004 to 2011.[6] As principal investigator on NIH/NHGRI grant U01HG004571, "Comprehensive Identification of ENCODE RNA Based Cis-Regulatory Elements," his laboratory used an NGS-based RIP-Seq assay to identify cis-regulatory elements and RNA-binding protein binding sites.[6][5] He co-authored two ENCODE consortium papers that have collectively been cited approximately 5,000 times, including "An integrated encyclopedia of DNA elements in the human genome" and "A user's guide to the encyclopedia of DNA elements (ENCODE)."[3][15][16]

RNA nanotechnology

Tenenbaum's laboratory has applied nanotechnology approaches to the study of RNA structure and function, including optical tweezers for single-molecule RNA manipulation, surface-enhanced Raman spectroscopy (SERS) for single-molecule protein detection, and studies of RNA kissing-complex structures.[17][18]

Structurally interacting RNA (sxRNA)

Since the early 2010s, Tenenbaum's research has focused on structurally interacting RNA (sxRNA), a platform in which one RNA molecule binds to induce a predictable structural switch in another, developed as a tool for post-transcriptional control of gene expression.[3][19] The 2017 Scientific Reports publication identified Tenenbaum and Francis Doyle as inventors on related intellectual property and reported a licensing agreement with HocusLocus, LLC.[19]

Biotechnology entrepreneurship

Tenenbaum has founded or co-founded four biotechnology companies based on inventions from his laboratory:[6]

Autoimmune Technologies (1996) — Tulane University's first biotechnology spin-off, commercializing a patented fibromyalgia diagnostic. Ribonomics (2002) — a post-transcriptional gene expression profiling company established at Duke University to commercialize RIP and ribonomic profiling technologies. HocusLocus, LLC (2009) — a biomanufacturing and molecular tools company, among the first biotechnology startups at SUNY Albany, commercializing RNA-based biomanufacturing technologies from the Tenenbaum lab. sxRNA Technologies, Inc. (2017) — commercializes the patented sxRNA platform for molecular tools, diagnostics, therapeutics, and stem cell manufacturing markets; Tenenbaum serves as Founder and CEO.[7]

In 2025, sxRNA Technologies secured new funding, as reported by the University at Albany.[20]

Patents

Tenenbaum holds 19 patents, granted or pending, focused primarily on RNA nanotechnology (sxRNA), post-transcriptional gene regulation (ribonomics), and molecular switch platforms.[6][21]

Trans-acting and structurally interacting RNA switches (sxRNA) and cell selection

US Patent 11,254,935 — Methods and Compositions for Use of Non-Coding RNA in Cell Culturing and Selection US Patent 9,719,085 — Trans-Acting RNA Switches (three-way junction logic constructs) US Patent 8,841,438 — Trans-Acting RNA Switches (conformational gene regulation constructs) US Patent Application 20150045414 — Trans-Acting RNA Switches (continuation filing) WIPO Provisional Application 60/917,155 — international priority filing for RNA switch components

Ribonomics and molecular pathologies

US Patent 8,815,517 — Methods for identifying functionally related genes and drug targets US Patent 8,143,002 — Methods for isolating and characterizing endogenous mRNA-protein (mRNP) complexes US Patent 7,432,052 — Identification of downstream mRNA ligands to FMRP and their role in fragile X syndrome US Patent 6,635,422 — Methods for isolating and characterizing endogenous mRNA-protein (mRNP) complexes US Patent Application 20060257857 — Methods for identifying functionally related genes and drug targets

Computational genomics and data processing

US Patent Application 20080281819 — Non-Random Control Data Set Generation for Facilitating Genomic Data Processing US Patent Application 20080281818 — Segmented Storage and Retrieval of Nucleotide Sequence Information US Patent Application 20080281530 — Genomic Data Processing Utilizing Correlation Analysis of Nucleotide Loci

Disease-specific target identification and diagnostics

US Patent 5,834,215 — Method for Detecting Antipolymer Antibodies and a Diagnostic Test Kit for Silicone-Related Diseases US Patent 5,620,859 — Method for Detecting Antipolymer Antibodies and Immunoassay Diagnostic System (licensed to Autoimmune Inc.) WIPO PCT/WO1997/014963A1 — international application for antipolymer antibody detection systems

Research funding

Tenenbaum has served as principal investigator or co-principal investigator on more than $14 million in federally funded research support from the NIH and NSF, including:[6]

1R01GM125870 (PI) 2018–2023, NIH/NIGMS — Development of a Structurally Interacting RNA (sxRNA) Technology U01HG004571 (PI) 2007–2013, NIH/NHGRI — Comprehensive Identification of ENCODE RNA Based Cis-Regulatory Elements[5] 1R41AG081123 / STTR Phase II 2R44AG081123 (PI/Co-PI), NIH/NIA — sxRNA-based organoid research for Alzheimer's disease 1R56DE033253 (Co-PI), NIH/NIDCR, 2023–2025 — Senescence and Salivary Gland Dysfunction R42GM114935 (Co-PI), NIH/NIGMS, 2017–2019 — sxRNA-based biopharmaceutical manufacturing 1R21HG008495 (PI), NIH/NHGRI, 2015–2017 — Trans-Regulation of RNA-Binding Protein Motifs by MicroRNA R01GM096471 (Co-PI), NIH/NIGMS, 2010–2015 — Molecular mechanisms underlying human RPE plasticity

Honors and awards

2026 — Outstanding Student Mentoring Award, College of Nanoscale Science and Engineering, University at Albany[6] 2025 — Excellence in Research and Entrepreneurship Award, The RNA Institute, University at Albany[6] 2025 — Alan Rothschild Innovation Pitch Award, Upstate CNYBAC[3] 2025 — SUNY Research Foundation S4 Pitch Event winner[3] 2010 — SUNY Excellence in Research Award, University at Albany[6] 2008 — SUNY Research Foundation Rising Star Award[6] 2007 — Golden Apple Teaching Award, UAlbany School of Public Health[6] 2001 — Robert & Barbara Bell Science of Cancer Award, Duke Comprehensive Cancer Center[6] 2000 — James A. Wilson, M.D. Fellow in Cancer Award, Duke Comprehensive Cancer Center[6] 1994 — Judith Graham Pool Postdoctoral Fellowship, National Hemophilia Foundation[6]

Professional service

Tenenbaum has served as a grant reviewer for the NIH (2004–present) and ad hoc reviewer for the NSF (2004–present).[6] He has held editorial board positions with the Journal of Experimental Biology (2012–present), Frontiers in Genetics (Non-Coding RNA, 2009–present), and the International Journal of Stem Cells (2009–present), and previously served as Associate Editor of Virology Journal (2005–2011).[6] He was a member of the NIH/NHGRI ENCODE Consortium (2004–2011) and has reviewed for journals including Science, Cell, Molecular Cell, PNAS, Nature, and RNA.[6] He has been profiled as a conference speaker on cell culture and biomanufacturing topics.[22]

Personal life

Tenenbaum was born and raised in St. Louis, Missouri, and attended Ladue High School.[citation needed] He has been married since 1992 to Dr. Diane (Cantor) Tenenbaum, a pediatrician whom he met while at Tulane University.[1][2][8] Together they have three sons: Max, Zachary, and Samuel.[1][2]

Selected publications

Tenenbaum has co-authored 64 peer-reviewed publications with over 14,000 total citations and an h-index of 34.[6] Selected publications include:

Tenenbaum SA, Carson CC, Lager PJ, Keene JD. "Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays." Proc Natl Acad Sci U S A. 2000;97(26):14085-90.[10] Tenenbaum SA, Lager PJ, Carson CC, Keene JD. "Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays." Methods. 2002;26(2):191-8.[13] Keene JD, Tenenbaum SA. "Eukaryotic mRNPs may represent posttranscriptional operons." Mol Cell. 2002;9(6):1161-7.[11] "An integrated encyclopedia of DNA elements in the human genome." ENCODE Project Consortium. Nature. 2012;489(7414):57-74.[15] Doyle F, Tenenbaum SA. "Trans-regulation of RNA-binding protein motifs by microRNA." Front Genet. 2014;5:79.[23] Jayaseelan S, Doyle F, Tenenbaum SA. "Profiling post-transcriptionally networked mRNA subsets using RIP-Chip and RIP-Seq." Methods. 2014;67(1):13-9.[14] Doyle F, Lapsia S, Spadaro S, Wurz ZE, Bhaduri-McIntosh S, Tenenbaum SA. "Engineering Structurally Interacting RNA (sxRNA)." Sci Rep. 2017;7:45393.[19] Huang K, Doyle F, Wurz ZE, Tenenbaum SA, Hammond RK, Caplan JL, Meyers BC. "FASTmiR: an RNA-based sensor for in vitro quantification and live-cell localization of small RNAs." Nucleic Acids Res. 2017;45(14):e130.[24] "A user's guide to the encyclopedia of DNA elements (ENCODE)." ENCODE Project Consortium. PLoS Biol. 2011;9(4):e1001046.[16] Muralidharan-Chari V, Wurz Z, Doyle F, Henry M, Diendorfer A, Tenenbaum SA, Borth N, Eveleth E, Sharfstein ST. "PTSelect™: A post-transcriptional technology that enables rapid establishment of stable CHO cell lines." J Biotechnol. 2021;325:360-371.

University at Albany faculty profile The RNA Institute — Faculty & Staff sxRNA Technologies, Inc. Google Scholar profile ResearchGate profile ORCID profile Justia Patents — inventor profile "Tell Me More: Scott Tenenbaum" — New York I-Corps interview SUNY TAF Class of 2025 — University at Albany Scott Tenenbaum profile — Scientia Magazine Scott Tenenbaum — Gradlum profile Scott Tenenbaum — LinkedIn

References

  1. ^ a b c d Obituary of Barbara Cantor, identifying Diane (Cantor) Tenenbaum and sons Max, Zachary, and Sam Tenenbaum.
  2. ^ a b c d Obituary of David Cantor, independently identifying Diane (Cantor) Tenenbaum and sons Max, Zachary, and Samuel.
  3. ^ a b c d e f g h i j k l m n NIH Biographical Sketch, TENENBAUM, SCOTT ALLEN, SciENcv, certified April 5, 2026.
  4. ^ University at Albany faculty profile, https://www.albany.edu/nanoscale-science-engineering/faculty/scott-tenenbaum
  5. ^ a b c ENCODE Project award page, U01HG004571, https://www.encodeproject.org/awards/U01HG004571/
  6. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z Tenenbaum, Scott A. CV for the National Academy of Inventors, 2026.
  7. ^ a b sxRNA Technologies, Inc., https://www.sxrna.com/
  8. ^ a b "Tell Me More: Scott Tenenbaum, Professor, College of Nanotechnology, Science, and Engineering." New York I-Corps. https://www.newyorkicorps.org/post/tell-me-more-scott-tenenbaum-professor-college-of-nanotechnology-science-and-engineering-depar
  9. ^ The RNA Institute, Faculty & Staff. https://www.albany.edu/rna/rna-institute-faculty-staff
  10. ^ a b Tenenbaum SA, Carson CC, Lager PJ, Keene JD. "Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays." Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14085-90. https://pubmed.ncbi.nlm.nih.gov/?term=tenenbaum+sa&size=100
  11. ^ a b Keene JD, Tenenbaum SA. "Eukaryotic mRNPs may represent posttranscriptional operons." Mol Cell. 2002 Jun;9(6):1161-7. https://pubmed.ncbi.nlm.nih.gov/?term=tenenbaum+sa&size=100
  12. ^ Culjkovic-Kraljacic B, Borden KLB. "The Impact of Post-transcriptional Control: Better Living Through RNA Regulons." Frontiers in Genetics. 2018;9:512. DOI: 10.3389/fgene.2018.00512.
  13. ^ a b Tenenbaum SA, Lager PJ, Carson CC, Keene JD. "Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays." Methods. 2002 Feb;26(2):191-8. https://pubmed.ncbi.nlm.nih.gov/?term=tenenbaum+sa&size=100
  14. ^ a b Jayaseelan S, Doyle F, Tenenbaum SA. "Profiling post-transcriptionally networked mRNA subsets using RIP-Chip and RIP-Seq." Methods. 2014 May 1;67(1):13-9. https://pubmed.ncbi.nlm.nih.gov/?term=tenenbaum+sa&size=100
  15. ^ a b "An integrated encyclopedia of DNA elements in the human genome." ENCODE Project Consortium. Nature. 2012 Sep 6;489(7414):57-74.
  16. ^ a b "A user's guide to the encyclopedia of DNA elements (ENCODE)." ENCODE Project Consortium. PLoS Biol. 2011 Apr;9(4):e1001046. https://pubmed.ncbi.nlm.nih.gov/21526222/
  17. ^ Almehmadi LM, Curley SM, Tokranova NA, Tenenbaum SA, Lednev IK. "Surface Enhanced Raman Spectroscopy for Single Molecule Protein Detection." Sci Rep. 2019 Aug 26;9(1):12356.
  18. ^ Stephenson W, Asare-Okai PN, Chen AA, Keller S, Santiago R, Tenenbaum SA, Garcia AE, Fabris D, Li PT. "The essential role of stacking adenines in a two-base-pair RNA kissing complex." J Am Chem Soc. 2013 Apr 17;135(15):5602-11.
  19. ^ a b c Doyle F, Lapsia S, Spadaro S, Wurz ZE, Bhaduri-McIntosh S, Tenenbaum SA. "Engineering Structurally Interacting RNA (sxRNA)." Sci Rep. 2017 Mar 28;7:45393. https://pubmed.ncbi.nlm.nih.gov/?term=tenenbaum+sa&size=100
  20. ^ "UAlbany Spinoff Secures New Funding, Bid to Transform Biotechnology." University at Albany News Center, 2025. https://www.albany.edu/news-center/news/2025-ualbany-spinoff-secures-new-funding-bid-transform-biotechnology
  21. ^ Justia Patents, Inventor: Scott A. Tenenbaum. https://patents.justia.com/inventor/scott-a-tenenbaum
  22. ^ Terrapinn, Cell Culture World Congress USA, Speaker: Scott Tenenbaum. https://www.terrapinn.com/conference/cell-culture-world-congress-usa/speaker-scott-TENENBAUM.stm
  23. ^ Doyle F, Tenenbaum SA. "Trans-regulation of RNA-binding protein motifs by microRNA." Front Genet. 2014 Apr 15;5:79. https://pubmed.ncbi.nlm.nih.gov/?term=tenenbaum+sa&size=100
  24. ^ Huang K, Doyle F, Wurz ZE, Tenenbaum SA, Hammond RK, Caplan JL, Meyers BC. "FASTmiR: an RNA-based sensor for in vitro quantification and live-cell localization of small RNAs." Nucleic Acids Res. 2017 Aug 21;45(14):e130. https://pubmed.ncbi.nlm.nih.gov/?term=tenenbaum+sa&size=100

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