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Donald MacDonald or Donald Macdonald may refer to:

Military personnel

Donald MacDonald (army officer) (c. 1724 – 1760), Scottish military officer who saw service for France, Charles Edward Stuart, and Great Britain
Donald Alexander Macdonald (1817–1896), Canadian politician and lieutenant governor of Ontario
Donald Alexander Macdonald (general) (1845–1920), Canadian general
Donald Balloch MacDonald (died c. 1476), Scottish-Gaelic lord

Donald MacDonald (Alberta politician) or Don MacDonald (fl. 1992–1993), Canadian politician, member of the Alberta legislature
Donald Macdonald (Australian politician) (1886–1962), Australian politician and Presbyterian minister
Donald MacDonald (Nova Scotia politician) (1909–1986), Canadian politician, social democrat and trade unionist
Donald MacDonald (Saskatchewan politician, born 1886) (1886–1970)
Donald A. MacDonald (c. 1849 –1884), Canadian farmer, member of the Prince Edward Island legislature
Donald Alexander Macdonald (1817–1896), Canadian politician and lieutenant governor of Ontario
Donald C. MacDonald (1913–2008), Canadian politician, leader of the Ontario New Democratic Party and the Ontario Co-operative Commonwealth Federation
Donald Forrest MacDonald (born 1937), politician in Saskatchewan, Canada
Donald Stovel Macdonald (1932–2018), Canadian politician and cabinet minister in the government of Pierre Trudeau

Donald MacDonald (actor) (1886–1972), American film actor and film director
Donald Macdonald (minister) (1825–1901), founding minister of the Free Presbyterian Church of Scotland
- Donald MacDonald (preacher) (1825–1901), Scottish preacher
Donald MacDonald (pastoralist) (1857–1937), Australian pastoralist
Donald MacDonald (poet) or Dòmhnall Ruadh Chorùna (1887–1967), North Uist stonemason and war poet in the Scottish Gaelic language
Donald Macdonald (rugby league) or Don Macdonald (died 1994), Australian rugby league referee
Donald MacDonald (rugby union) (born 1951), Scottish rugby player
Donald MacDonald (stained glass) (1841–1916), American stained glass artist
Donald Alaster Macdonald (1859–1932), Australian sports journalist and war correspondent
Donald Gorm MacDonald of Carey (died 1586)
Sir Donald Gorme Og Macdonald, 1st Baronet (died 1643)
Donald Stone Macdonald (1919–1993), American academic who specialized in Korean studies