Neurological complication of persistently high blood sugar
Diabetic neuropathy includes various types of nerve damage associated with diabetes mellitus. The most common form, diabetic peripheral neuropathy, affects 30% of all diabetic patients.[1][2] Symptoms depend on the site of nerve damage and can include motor changes such as weakness; sensory symptoms such as numbness, tingling, or pain; or autonomic changes such as urinary symptoms. These changes are thought to result from a microvascular injury involving small blood vessels that supply nerves (vasa nervorum). Relatively common conditions which may be associated with diabetic neuropathy include distal symmetric polyneuropathy; third, fourth, or sixth cranial nerve palsy;[3]mononeuropathy; mononeuropathy multiplex; diabetic amyotrophy; and autonomic neuropathy.
Signs and symptoms
Diabetic neuropathy can affect any peripheral nerves including sensory neurons, motor neurons, and the autonomic nervous system. Therefore, diabetic neuropathy has the potential to affect essentially any organ system and can cause a range of symptoms. There are several distinct syndromes based on the organ systems affected.[citation needed]
Sensorimotor polyneuropathy
Longer nerve fibers are affected to a greater degree than shorter ones because nerve conduction velocity is slowed in proportion to a nerve's length. In this syndrome, decreased sensation and loss of reflexes occur first in the toes on each foot, then extend upward. It is usually described as a glove-stocking distribution of numbness, sensory loss, dysesthesia and nighttime pain. The pain can feel like burning, pricking sensation, achy or dull. A pins and needles sensation is common. Loss of proprioception, the sense of where a limb is in space, is affected early. These patients cannot feel when they are stepping on a foreign body, like a splinter, or when they are developing a callus from an ill-fitting shoe. Consequently, they are at risk of developing ulcers and infections on the feet and legs, which can lead to amputation. Similarly, these patients can get multiple fractures of the knee, ankle or foot, and develop a Charcot joint. Loss of motor function results in dorsiflexion, contractures of the toes, and loss of the interosseous muscle function that leads to contraction of the digits, so-called hammer toes. These contractures occur not only in the foot but also in the hand where the loss of the musculature makes the hand appear gaunt and skeletal. The loss of muscular function is progressive.[citation needed]
Gastrointestinal manifestations include gastroparesis, nausea, bloating, and diarrhea. Because many diabetics take oral medication for their diabetes, absorption of these medicines is greatly affected by the delayed gastric emptying. This can lead to hypoglycemia when an oral diabetic agent is taken before a meal and does not get absorbed until hours, or sometimes days later when there is normal or low blood sugar already. Sluggish movement of the small intestine can cause bacterial overgrowth, made worse by the presence of hyperglycemia. This leads to bloating, gas and diarrhea.[citation needed]
When cranial nerves are affected, neuropathies of the oculomotor nerve (cranial nerve #3 or CNIII) are most common. The oculomotor nerve controls all the muscles that move the eye except for the lateral rectus and superior oblique muscles. It also serves to constrict the pupil and open the eyelid. The onset of a diabetic third nerve palsy is usually abrupt, beginning with frontal or pain around the eye and then double vision. All the oculomotor muscles innervated by the third nerve may be affected, but those that control pupil size are usually well-preserved early on. This is because the parasympathetic nerve fibers within CNIII that influence pupillary size are found on the periphery of the nerve (in terms of a cross-sectional view), which makes them less susceptible to ischemic damage (as they are closer to the vascular supply). The sixth nerve, the abducens nerve, which innervates the lateral rectus muscle of the eye (moves the eye laterally), is also commonly affected but fourth nerve, the trochlear nerve, (innervates the superior oblique muscle, which moves the eye downward) involvement is unusual. Damage to a specific nerve of the thoracic or lumbar spinal nerves can occur and may lead to painful syndromes that mimic a heart attack, gallbladder inflammation, or appendicitis. Diabetics have a higher incidence of entrapment neuropathies, such as carpal tunnel syndrome.
Pathogenesis
The following processes are thought to be involved in the development of diabetic neuropathy:
Vascular and neural diseases are closely related. Blood vessels depend on normal nerve function, and nerves depend on adequate blood flow. The first pathological change in the small blood vessels is narrowing of the blood vessels. As the disease progresses, neuronal dysfunction correlates closely with the development of blood vessel abnormalities, such as capillarybasement membrane thickening and endothelial hyperplasia, which contribute to diminished oxygen tension and hypoxia. Neuronal ischemia is a well-established characteristic of diabetic neuropathy. Blood vessel opening agents (e.g., ACE inhibitors, α1-antagonists) can lead to substantial improvements in neuronal blood flow, with corresponding improvements in nerve conduction velocities. Thus, small blood vessel dysfunction occurs early in diabetes, parallels the progression of neural dysfunction, and may be sufficient to support the severity of structural, functional, and clinical changes observed in diabetic neuropathy.
Elevated levels of glucose within cells cause a non-enzymatic covalent bonding with proteins, which alters their structure and inhibits their function. Some of these glycated proteins have been implicated in the pathology of diabetic neuropathy and other long-term complications of diabetes.
Also called the sorbitol/aldose reductase pathway, the polyol pathway appears to be implicated in diabetic complications, especially in microvascular damage to the retina,[4]kidney,[5] and nerves.[6]
Diagnosis
Diabetic peripheral neuropathy can be diagnosed with a history and physical examination. The diagnosis is considered in people who develop pain or numbness in a leg or foot with a history of diabetes. Muscle weakness, pain, balance loss, and lower limb dysfunction are the most common clinical manifestations.[7] Physical exam findings may include changes in appearance of the feet, presence of ulceration, and diminished ankle reflexes. The most useful physical examination finding for large fiber neuropathy is an abnormally decreased vibration perception to a 128-Hz tuning fork (likelihood ratio (LR) range, 16–35) or pressure sensation with a 5.07 Semmes-Weinstein monofilament (LR range, 11–16). Normal results on vibration testing (LR range, 0.33–0.51) or monofilament (LR range, 0.09–0.54) make large fiber peripheral neuropathy from diabetes less likely.[8]Nerve conduction tests may show reduced functioning of the peripheral nerves, but seldom correlate with the severity of diabetic peripheral neuropathy and are not appropriate as routine tests for the condition.[9] Small fiber neuropathy measured by QST and Sudomotor function tests, through electrochemical skin conductance, is more and more indicated to assess early signs of diabetic neuropathy[10][11][12] and autonomic neuropathy.[13]
Classification
Diabetic neuropathy encompasses a series of different neuropathic syndromes which can be categorized as follows:[14]
Multiple lesions, affecting nerves that don't follow a specific pattern, also called "mononeuritis multiplex"
Nerve damage from entrapment (e.g. median, ulnar, peroneal)
Symmetrical neuropathies:
Sensory
Autonomic
Distal symmetrical polyneuropathy (DSPN), the diabetic type of which is also known as diabetic peripheral neuropathy (DPN) (most common presentation)
Prevention
This section needs expansion. You can help by adding to it. (March 2017)
Diabetic neuropathy can be largely prevented by maintaining blood glucose levels and lifestyle modifications.[15][16] Enhanced glucose control methods include more frequent subcutaneous insulin administration, continuous insulin infusion, oral antidiabetic agents, while lifestyle modifications may include exercise alone, or in combination with dietary modifications. Enhanced glucose control prevents the development of clinical neuropathy and reduces nerve abnormalities in type 1 diabetes, and delays the onset of neuropathy in both types of diabetes. However, such methods may increase the likelihood of experiencing a hypoglycemic event, and many of these more aggressive methods require more frequent insulin use which has been associated with excessive risk of falls.[17]
Treatment
Blood glucose management
Treatment of early manifestations of sensorimotor polyneuropathy involves improving glycemic control.[18] Tight control of blood glucose can reverse the changes of diabetic neuropathy if the neuropathy and diabetes are recent in onset. This is the primary treatment of diabetic neuropathy that may change the course of the condition as the other treatments focus on reducing pain and other symptoms.
Topical agents
Capsaicin applied to the skin in a 0.075% concentration has not been found to be more effective than placebo for treating pain associated with diabetic neuropathy. There is insufficient evidence to draw conclusions for more concentrated forms of capsaicin, clonidine, or lidocaine applied to the skin.[19] About 10% of people who use capsaicin cream have a large benefit.[20]
The only three medications approved by the United States' Food and Drug Administration for diabetic peripheral neuropathy (DPN) are the antidepressant duloxetine, the anticonvulsant pregabalin, and the long-acting opioidtapentadol ER (extended release).[24][25] Before trying a systemic medication, some doctors recommend treating localized diabetic peripheral neuropathy with lidocaine patches.[9]
As above, the serotonin-norepinephrine reuptake inhibitors (SNRIs) duloxetine and venlafaxine are recommended in multiple medical guidelines as first or second-line therapy for DPN.[26] A 2017 systematic review and meta-analysis of randomized controlled trials concluded there is moderate quality evidence that duloxetine and venlafaxine each provide a large benefit in reducing diabetic neuropathic pain.[19] Common side effects include dizziness, nausea, and sleepiness.[19]
Tricyclic antidepressants
TCAs include imipramine, amitriptyline, desipramine, and nortriptyline. They are generally regarded as first or second-line treatment for DPN.[26] Of the TCAs, imipramine has been the best studied.[19] These medications are effective at decreasing painful symptoms but lead to multiple side effects that are dose-dependent.[19] One notable side effect is cardiac toxicity, which can lead to fatal abnormal heart rhythms. Additional common side effects include dry mouth, difficulty sleeping, and sedation.[19] At low dosages used for neuropathy, toxicity is rare,[citation needed] but if symptoms warrant higher doses, complications are more common. Among the TCAs, amitriptyline is most widely used for this condition, but desipramine and nortriptyline have fewer side effects.
Opioids
Typical opioid medications, such as oxycodone, appear to be no more effective than placebo. In contrast, low-quality evidence supports a moderate benefit from the use of atypical opioids (e.g., tramadol and tapentadol), which also have SNRI properties.[19] Opioid medications are recommended as second or third-line treatment for DPN.[26]
Medical devices
Monochromatic infrared photo energy treatment (MIRE) has been shown to be an effective therapy in reducing and often eliminating pain associated with diabetic neuropathy.[citation needed] The studied wavelength of 890 nm is able to penetrate into the subcutaneous tissue where it acts upon a specialized part of the cell called the cytochrome C. The infrared light energy prompts the cytochrome C to release nitric oxide into the cells. The nitric oxide in turn promotes vasodilation which results in increased blood flow that helps nourish damaged nerve cells. Once the nutrient rich blood is able to reach the affected areas (typically the feet, lower legs and hands) it promotes the regeneration of nerve tissues and helps reduce inflammation thereby reducing and/or eliminating pain in the area.
Gait training, posture training, and teaching these patients the basic principles of off-loading can help prevent and/or stabilize foot complications such as foot ulcers.[28] Off-loading techniques can include the use of mobility aids (e.g. crutches) or foot splints.[28] Gait re-training would also be beneficial for individuals who have lost limbs, due to diabetic neuropathy, and now wear a prosthesis.[28]
Exercise programs, along with manual therapy, will help to prevent muscle contractures, spasms and atrophy. These programs may include general muscle stretching to maintain muscle length and a person's range of motion.[30] General muscle strengthening exercises will help to maintain muscle strength and reduce muscle wasting.[31] Aerobic exercise such as swimming and using a stationary bicycle can help peripheral neuropathy, but activities that place excessive pressure on the feet (e.g. walking long distances, running) may be contraindicated.[32] Exercise therapy has been shown to increase the blood flow to the peripheral nerves, can improve gait function.[33]
Diabetic peripheral neuropathy (DPN) with superimposed nerve compression may be treatable in the limbs with multiple nerve decompressions.[34][35] The theory behind this procedure is that DPN predisposes patients to nerve compression at anatomic areas of narrowing, and that a majority of symptoms of DPN are actually attributable to nerve entrapment, a treatable condition.[36] Multiple systematic reviews have found that nerve decompression surgery for DPN is associated with lower pain scores, higher two-point discrimination (a measure of sensory improvement), lower rate of ulcerations, fewer falls (in the case of lower extremity decompression), and fewer amputations.[37][34][35][38][39] Multiple nerve decompression surgery is unusual in that it can reverse some symptoms (e.g. lower pain and increased sensation), while also providing protection against serious foot complications (e.g. ulcers and amputations).[37]
Other
Low-quality evidence supports a moderate-large beneficial effect of botulinum toxin injections.[19] There is insufficient evidence to draw firm conclusions for the utility of the cannabinoidsnabilone and nabiximols.[19]
Prognosis
The mechanisms of diabetic neuropathy are poorly understood. At present, treatment alleviates pain and can control some associated symptoms, but the process is generally progressive.
As a complication, there is an increased risk of injury to the feet because of loss of sensation (see diabetic foot). Small infections can progress to ulceration and this may require amputation.[40]
Epidemiology
Globally diabetic neuropathy affects approximately 132 million people as of 2010 (1.9% of the population).[41]
Diabetes is the leading known cause of neuropathy in developed countries, and neuropathy is the most common complication and greatest source of morbidity and mortality in diabetes. A systematic review has found that diabetic peripheral neuropathy affects 30% of diabetes patients.[1] Diabetic neuropathy is implicated in 50–75% of nontraumatic amputations.
The main risk factor for diabetic neuropathy is hyperglycemia. In the DCCT (Diabetes Control and Complications Trial, 1995) study, the annual incidence of neuropathy was 2% per year but dropped to 0.56% with intensive treatment of Type 1 diabetics. The progression of neuropathy is dependent on the degree of glycemic control in both Type 1 and Type 2 diabetes. Duration of diabetes, age, cigarette smoking, hypertension, height, and hyperlipidemia are also risk factors for diabetic neuropathy.
^ abSun J, Wang Y, Zhang X, Zhu S, He H (October 2020). "Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis". Prim Care Diabetes. 14 (5): 435–444. doi:10.1016/j.pcd.2019.12.005. PMID31917119.
^Iqbal Z, Azmi S, Yadav R, Ferdousi M, Kumar M, Cuthbertson DJ, Lim J, Malik RA, Alam U (June 2018). "Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy". Clin Ther. 40 (6): 828–849. doi:10.1016/j.clinthera.2018.04.001. PMID29709457.
^Behl T, Kaur I, Kotwani A (Jun 2015). "Implication of oxidative stress in progression of diabetic retinopathy". Survey of Ophthalmology. 61 (2): 187–96. doi:10.1016/j.survophthal.2015.06.001. PMID26074354.
^Kanji JN, Anglin RE, Hunt DL, Panju A (April 2010). "Does this patient with diabetes have large-fiber peripheral neuropathy?". JAMA. 303 (15): 1526–32. doi:10.1001/jama.2010.428. PMID20407062.
^Selvarajah, D.; Kar, D.; Khunti, K.; Davies, M. J.; Scott, A. R.; Walker, J.; & Tesfaye, S. (2019). "Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention" (PDF). The Lancet Diabetes & Endocrinology. 7 (12): 938–948. doi:10.1016/S2213-8587(19)30081-6. PMID 31624024
^Casellini, C. M.; Parson, H. K.; Richardson, M. S.; Nevoret, M. L.; & Vinik, A. I. (2013). "Sudoscan, a noninvasive tool for detecting diabetic small fiber neuropathy and autonomic dysfunction". Diabetes Technology & Therapeutics. 15 (11): 948–953. doi:10.1089/dia.2013.0129. PMC 3817891. PMID 23889506
^Yajnik, C. S.; Kantikar, V.; Pande, A.; Deslypere, J. P.; Dupin, J.; Calvet, J. H.; & Bauduceau, B. (2013). "Screening of cardiovascular autonomic neuropathy in patients with diabetes using non-invasive quick and simple assessment of sudomotor function". Diabetes & Metabolism. 39 (2): 126–131. doi:10.1016/j.diabet.2012.09.004. PMID 23159130
^d'Amato, C.; Greco, C.; Lombardo, G.; Frattina, V.; Campo, M.; Cefalo, C. M.; ... & Spallone, V. (2020). "The diagnostic usefulness of the combined COMPASS 31 questionnaire and electrochemical skin conductance for diabetic cardiovascular autonomic neuropathy and diabetic polyneuropathy". Journal of the Peripheral Nervous System. 25 (1): 44–53. doi:10.1111/jns.12366. PMID 31985124. S2CID 210924747
^Veves, A.; Giurini, J. M.; LoGerfo, F. W. (2012). The Diabetic Foot: Medical and Surgical Management (3rd ed.). Springer Science & Business Media. p. 34. ISBN978-1-61779-791-0.
^"The effect of intensive diabetes therapy on the development and progression of neuropathy. The Diabetes Control and Complications Trial Research Group". Annals of Internal Medicine. 122 (8): 561–8. April 1995. doi:10.7326/0003-4819-122-8-199504150-00001. PMID7887548. S2CID24754081.
^ abcdefghijklmnWaldfogel JM, Nesbit SA, Dy SM, Sharma R, Zhang A, Wilson LM, et al. (May 2017). "Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life: A systematic review". Neurology (Systematic Review & Meta-Analysis). 88 (20): 1958–1967. doi:10.1212/WNL.0000000000003882. PMID28341643. S2CID40159060.
^ abcdZiegler D, Fonseca V (January–February 2015). "From guideline to patient: a review of recent recommendations for pharmacotherapy of painful diabetic neuropathy". Journal of Diabetes and Its Complications (Review). 29 (1): 146–56. doi:10.1016/j.jdiacomp.2014.08.008. PMID25239450.
^Wiktorsson-Möller M, Oberg B, Ekstrand J, Gillquist J (July 1983). "Effects of warming up, massage, and stretching on range of motion and muscle strength in the lower extremity". The American Journal of Sports Medicine. 11 (4): 249–52. doi:10.1177/036354658301100412. PMID6614296. S2CID39037628.
^ abTu Y, Lineaweaver WC, Chen Z, Hu J, Mullins F, Zhang F (March 2017). "Surgical Decompression in the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-analysis". J Reconstr Microsurg. 33 (3): 151–157. doi:10.1055/s-0036-1594300. PMID27894152.
^Tu Y, Lineaweaver WC, Chen Z, Hu J, Mullins F, Zhang F (March 2017). "Surgical Decompression in the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-analysis". J Reconstr Microsurg. 33 (3): 151–157. doi:10.1055/s-0036-1594300. PMID27894152.
Bril V, England JD, Franklin GM, Backonja M, Cohen JA, Del Toro DR, et al. (June 2011). "Evidence-based guideline: treatment of painful diabetic neuropathy--report of the American Association of Neuromuscular and Electrodiagnostic Medicine, the American Academy of Neurology, and the American Academy of Physical Medicine & Rehabilitation". Muscle & Nerve. 43 (6): 910–7. doi:10.1002/mus.22092. hdl:2027.42/84412. PMID21484835. S2CID15020212.
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