Desolation Sound has always been inhabited by tribes of the Tla'amin and falls within the traditional territories of the Klahoose First Nation, Tla'amin Nation, and Homalco First Nations. In the summer of 1792, two expeditions led by Captains George Vancouver, Dionisio Alcalá Galiano and Cayetano Valdés y Flores arrived and cooperated in mapping the sound.[2] Vancouver named it Desolation Sound, cryptically claiming that "there was not a single prospect that was pleasing to the eye".[3]
Refuge Cove is the only community in Desolation Sound. It is located on West Redonda Island and administered within Strathcona Regional District. The community serves as a centrally located supply stop for boaters and local fishers travelling in or near Desolation Sound.