Deborah Beth Zamble (October 5, 1971 – July 6, 2020) was a Canadian chemist and Canada Research Chair in Biological Chemistry at the University of Toronto. Her research considered how bacteria processed metal nutrients.
Zamble returned to Canada in 2001, where she was made a Canada Research Chair in Biological Chemistry.[2] Here she investigated how bacteria process metal nutrients, with a focus on the uptake of nickel.[3] Transition metals are essential to the structure and function of biological systems, but can be toxic if they are allowed to accumulate. To mitigate this, cells make use of metalloproteins to regulate the use of each metal. In particular, Zamble studies the bacteria Escherichia coli and Helicobacter pylori.[4]
Zamble, Deborah B.; Lippard, Stephen J. (1995). "Cisplatin and DNA repair in cancer chemotherapy". Trends in Biochemical Sciences. 20 (10): 435–439. doi:10.1016/S0968-0004(00)89095-7. PMID8533159.
Zamble, Deborah B.; Mu, David; Reardon, Joyce T.; Sancar, Aziz; Lippard, Stephen J. (1996-01-01). "Repair of Cisplatin−DNA Adducts by the Mammalian Excision Nuclease". Biochemistry. 35 (31): 10004–10013. doi:10.1021/bi960453+. ISSN0006-2960. PMID8756462.
Zamble, Deborah; Rowińska-Żyrek, Magdalena; Kozłowski, Henryk, eds. (24 March 2017). The Biological Chemistry of Nickel. Cambridge, U.K.: Royal Society of Chemistry. ISBN978-1-78801-058-0. OCLC1007052796.
^Zamble, Deborah B.; McClure, Craig P.; Penner-Hahn, James E.; Walsh, Christopher T. (2000-12-01). "The McbB Component of Microcin B17 Synthetase Is a Zinc Metalloprotein". Biochemistry. 39 (51): 16190–16199. doi:10.1021/bi001398e. ISSN0006-2960. PMID11123948.