After going undrafted in the 2010 NFL draft, Pender signed with the Philadelphia Eagles as an undrafted free agent on April 26, 2010. He was cut on September 3, 2010.
Baltimore Ravens
He was signed to the Baltimore Ravens practice squad on September 8, 2010. He was later waived on September 21.
Indianapolis Colts
Pender was signed to the Indianapolis Colts practice squad on November 10, 2010. He was promoted to the active roster on December 8, 2010. He was waived on December 27 having only played in 2 games for the Colts.
Cincinnati Bengals
Pender was claimed off waivers by the Cincinnati Bengals on December 28, 2010. He was waived on September 3.