Pasquesi starred in the short film Regrets that premiered An Event Apart, and co-starred in I Want Someone to Eat Cheese With.[2] He wrote for Exit 57 and Strangers with Candy, co-wrote and appeared[3] in the Spike TV series Factory, and co-wrote[4] and co-starred in Cop Show. In 2009, he was in the cast of Angels & Demons, where he played the character Claudio Vincenzi.[5] He co-created and co-wrote the new show Merkin Penal. Similar to his role of "Meat Man Stew" in Strangers With Candy, Pasquesi plays "Knife Man" in At Home with Amy Sedaris.
Since 2002, he has been performing with T. J. Jagodowski in the all improvised show "TJ and Dave".[7] In 2006, they began an Off Broadway run, performing monthly at The Barrow Street Theatre in New York City.[8] The Chicago Reader has described the show as "an hour of subtle character development, verbal facility, and pantomimic agility that anticipates and plays off the audience's reactions."[9] Guests of the show include August: Osage County'sTracy Letts, Academy Award Nominee Michael Shannon, SNL's Mike O'Brien, and Absinthe's Jet Eveleth. The 2009 South by Southwest Film Festival included the documentary Trust Us, This is All Made Up directed by Alex Karpovsky, which chronicles a "T.J. and Dave" performance.[10][11]