David Mervyn Blow

David Mervyn Blow FRS FInstP
Born	(1931-06-27)27 June 1931 Birmingham, England
Died	8 June 2004(2004-06-08) (aged 72) Appledore, Torridge (near Bideford), Devon, England
Education	Kingswood School[5]
Alma mater	University of Cambridge (BA, PhD)[5]
Known for	Haemoglobin X-ray crystallography
Spouse	Mavis Sears ​ (m. 1955)​ [5]
Awards	Wolf Prize in Chemistry (1987)
Scientific career
Fields	Biophysicist
Institutions	Massachusetts Institute of Technology National Institutes of Health Imperial College London MRC Laboratory of Molecular Biology
Thesis	X-ray analysis of haemoglobin : determination of phase angles by isomorphous substitution (1958)
Doctoral advisor	Max Perutz[1]
Other academic advisors	Alexander Rich[1]
Doctoral students	Richard Henderson[2][3] Paul Sigler[1] Alice Vrielink[4] Gérard Bricogne
Other notable students	Thomas A. Steitz Brian Matthews[1]

David Mervyn Blow FRS FInstP^[6] (27 June 1931 – 8 June 2004)^[5][7][8] was an influential British biophysicist. He was best known for the development of X-ray crystallography, a technique used to determine the molecular structures of tens of thousands of biological molecules. This has been extremely important to the pharmaceutical industry.^[9]

Early life and education

Blow was born in Birmingham, England. He was educated at Kingswood School in Bath, Somerset and the University of Cambridge where he won a scholarship to Corpus Christi College, Cambridge. His PhD was awarded in 1958 for X-ray analysis of haemoglobin supervised by Max Perutz at the MRC Laboratory of Molecular Biology (LMB).^[10][11]

Career and research

Following graduation from Cambridge, Blow spent two years at the Massachusetts Institute of Technology (MIT) and the National Institutes of Health (NIH) funded by the Fulbright Foundation^[5]

In 1954, he met Max Perutz;^[12] they began to study a new technique wherein X-rays would be passed through a protein sample at the MRC Laboratory of Molecular Biology. This eventually led to the creation of a three-dimensional structure of haemoglobin.^[13] Blow was appointed professor of biophysics at Imperial College London in 1977. His doctoral students include Richard Henderson,^[2][3] Paul Sigler,^[1] and Alice Vrielink.^[14]

Awards and honours

Blow was elected a Fellow of the Royal Society (FRS) in 1972. He was awarded the Wolf Prize in Chemistry in 1987.^[5]

Personal life

Blow married Mavis Sears in 1955, and they had two children, a son Julian and a daughter Elizabeth.^[5][8] He died of lung cancer at the age of 72, in Appledore, Torridge (near Bideford), Devon.^[7][8]

References

1. "David Blow Academic Genealogy". AcademicTree.org.
2. Henderson, Richard (1969). X-ray analysis of α-chymotrysin : substrate and inhibitor binding (PhD thesis). University of Cambridge. OCLC 500470310. EThOS uk.bl.ethos.458866.
3. Al-Khalili, Jim (2018). "Richard Henderson zooms in on the molecules of life". BBC.
4. Vrielink, Alice (3 July 2014). "David Blow (1931-2004) - A Remberance" (PDF). American Crystallographic Association. Archived (PDF) from the original on 3 July 2014. Retrieved 14 October 2021.
5. Anon (2017). "Blow, Prof. David Mervyn". Who's Who & Who Was Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U7898. (Subscription or UK public library membership required.)
6. Henderson, R.; Franks, N. P. (2009). "David Mervyn Blow. 27 June 1931 -- 8 June 2004". Biographical Memoirs of Fellows of the Royal Society. 55: 13–35. doi:10.1098/rsbm.2008.0022. S2CID 56616438.
7. Pearce, Jeremy (19 July 2007). "David Blow, 72; Briton Developed Method to Study Proteins". The New York Times.
8. Rossmann, Michael (25 June 2004). "David Blow Pioneering scientist in protein crystallography". The Guardian.
9. Vrielink, Alice (2005). "David Mervyn Blow". Physics Today. 58 (3): 88–89. Bibcode:2005PhT....58c..88V. doi:10.1063/1.1897573.
10. Blow, David Mervyn (1958). X-ray analysis of haemoglobin : determination of phase angles by isomorphous substitution. copac.jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 879392023. EThOS uk.bl.ethos.596730. Archived from the original on 16 February 2018. Retrieved 15 February 2018.
11. Henderson, R.; Franks, N. P. (2009). "David Mervyn Blow. 27 June 1931 — 8 June 2004". Biographical Memoirs of Fellows of the Royal Society. 55: 13–35. doi:10.1098/rsbm.2008.0022. ISSN 0080-4606. S2CID 56616438.
12. Blow, David Mervyn (2004). "Max Ferdinand Perutz OM CH CBE. 19 May 1914 – 6 February 2002: Elected F.R.S. 1954". Biographical Memoirs of Fellows of the Royal Society. 50: 227–256. doi:10.1098/rsbm.2004.0016. JSTOR 4140521. PMID 15768489. S2CID 73986989.
13. Rossmann, M. G.; Blow, D. M. (1962). "The detection of sub-units within the crystallographic asymmetric unit". Acta Crystallographica. 15 (1): 24–31. Bibcode:1962AcCry..15...24R. CiteSeerX 10.1.1.319.3019. doi:10.1107/S0365110X62000067. ISSN 0365-110X.
14. Vrielink, Alice (3 July 2014). "David Blow (1931-2004) - A Remberance" (PDF). American Crystallographic Association. Archived (PDF) from the original on 3 July 2014. Retrieved 14 October 2021.