Fofana began his career in the Ivory Coast with Abidjan City, before joining AFAD on loan in 2019.[3] He was heavily scouted by French, Belgian and Norwegian clubs.[4] On 2 February 2021, Fofana signed a professional contract with Norwegian club Molde on a free transfer, signing for four years.[5] He debuted with Molde in a 3–3 UEFA Europa League tie with Hoffenheim on 18 February 2021, scoring his side's third goal in the 74th minute.[6]
Chelsea
On 28 December 2022, it was announced that Fofana would join English Premier League side Chelsea on 1 January 2023.[7] On 8 January 2023, Fofana came off the bench to make his Chelsea debut in a 4–0 loss to Manchester City in the FA Cup.[8]
Loan to Union Berlin
On 11 July 2023, Chelsea announced that Fofana would join Bundesliga side Union Berlin on a season-long loan. [9] He was recalled by Chelsea on 11 January 2024.[10]
Loan to Burnley
Two days after returning to Chelsea, Fofana was loaned to fellow Premier League club Burnley until the end of the season.[11][12] On 3 February 2024, he scored his first goals for Burnley by netting a brace in a 2–2 draw against Fulham.[13] On 21 May 2024, Burnley confirmed the player was returning to Chelsea.[14]
Loan to Göztepe
On 13 September 2024, Fofana was loaned to newly-promoted Turkish club Göztepe until the end of the 2024–25 season.[15][16]