Wickersham enjoyed his most productive season for Detroit in 1964, when he went 19–12 with a 3.44 ERA and posted career-numbers in strikeouts (164), starts (36), complete games (11), appearances (40), and innings pitched (254.0). He was in consideration that year in the American League MVP vote.[1] His 19 victories also was a career-mark,[1] missing a 20-win season due to an ejection in his last start from a ballgame which was tied 1–1 in the 7th inning. Mickey Lolichrelieved him and earned a 4–2 win. Wickersham was ejected after calling time out three times to try to keep a base runner from advancing as Norm Cash argued with the call by Bill Valentine. Valentine later expressed regret for the call, saying he had been "too impulsive" in his ejection. However, Wickersham wrote him a letter in 2004, reassuring the ump that he made the right call, in an attempt to relieve him of his burden.[7][8]
Wickersham also pitched for the Pittsburgh Pirates and Kansas City Royals. He was traded by the Tigers to the Pirates for Dennis Ribant on November 28, 1967.[9] He played his final major league game on July 26, 1969, at the age of 33. Over his 10-season MLB career, Wickersham posted a 68–57 record with 638 strikeouts and a 3.66 ERA in 1,123 innings, including 29 complete games, five shutouts and 18 saves.[1] Notably, he was one of three players (along with fellow pitchers Aurelio Monteagudo and Moe Drabowsky) to play for both Kansas City-based major league teams, the Athletics and Royals.[10]
Wickersham married Carol Sue Larson in 1964. They remained married for 48 years until her death from cancer in 2012. Together, they had four children: Davey, Carey, Mandy, and Matthew.[11]
Wickersham died on June 18, 2022, at the age of 86.[8][12]