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Dedicator of cytokinesis protein 2 (Dock2) is a protein encoded in the human by the DOCK2 gene. Dock2 is a large (~180 kDa) protein involved in intracellular...
Click to read more »are risk factors in specific populations. For instance, an allele of the DOCK2 gene (dedicator of cytokinesis 2 gene) is a common risk factor in Asian...
Click to read more »representation of the protein domains for DOCK2 (mammalian homolog to CED-5) and ELMO1 (mammalian homolog for CED-12). On DOCK2/CED-5, the SH3-domain that binds...
Click to read more »their sequence homology: DOCK-A subfamily Dock180 (also known as Dock1) Dock2 Dock5 DOCK-B subfamily Dock3 (also known as MOCA and PBP) Dock4 DOCK-C subfamily...
Click to read more »Nagashima K, Matsuda M (1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins". Biochim. Biophys. Acta. 1452...
Click to read more »RASGRF2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3. DOCK1/DOCK180; DOCK2; DOCK3/MOCA; DOCK4; DOCK5; DOCK6/ZIR1; DOCK7/ZIR2; DOCK8/ZIR3; DOCK9/Zizimin1;...
Click to read more »STAT5b deficiency ITK deficiency SH2D1A deficiency (XLP1) MAGT1 deficiency DOCK2 deficiency DOCK8 deficiency RhoH deficiency Activated PI3K delta syndrome...
Click to read more »Kwofie MA, Skowronski J (2008). "Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors". J. Biol. Chem. 283 (6):...
Click to read more »PMC 2882961. PMID 12690205. Sanui T, Inayoshi A, Noda M, et al. (2003). "DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction...
Click to read more »interact with: Abl gene, BCAR1, BCR gene, CBLB, CD117, CD34, Cbl gene, Dock2, EPOR, GAB1, GAB2, INPP5D, MAP4K1, MAP4K5, NEDD9, PIK3R2, Paxillin RAPGEF1...
Click to read more »PMC 2887429. PMID 17765544. Reif K, Cyster J (2002). "The CDM protein DOCK2 in lymphocyte migration". Trends Cell Biol. 12 (8): 368–73. doi:10...
Click to read more »Nagashima K, Matsuda M (1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins". Biochim. Biophys. Acta. 1452...
Click to read more »HGNC:2985; Q14183 4453 DOC2B HGNC:2986; Q14184 4454 DOCK1 HGNC:2987; Q14185 4455 DOCK2 HGNC:2988; Q92608 4456 DOCK3 HGNC:2989; Q8IZD9 4457 DOCK4 HGNC:19192; Q8N1I0...
Click to read more »other DOCK-A/B family members (35% sequence identity with Dock180, 39% with Dock2 and 54% with Dock3). Dock4, however, contains a unique set of motifs at...
Click to read more »Kwofie MA, Skowronski J (2008). "Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors". J. Biol. Chem. 283 (6):...
Click to read more »Watanabe K, Sanematsu F, Sasazuki T, Sasaki T, Fukui Y (August 2006). "DOCK2 is a Rac activator that regulates motility and polarity during neutrophil...
Click to read more »Nagashima K, Matsuda M (Nov 1999). "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins". Biochim. Biophys. Acta. 1452...
Click to read more »Janardhan A, Swigut T, Hill B, et al. (January 2004). "HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis". PLOS Biol...
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