DIP2A

DIP2A
Identifiers
Aliases	DIP2A, C21orf106, DIP2, disco interacting protein 2 homolog A
External IDs	OMIM: 607711; MGI: 2385920; GeneCards: DIP2A
Enzyme activity
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,570,015 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,181,125 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; parietal pleura; ; tibia; ; cardia; ; ventral tegmental area; ; renal medulla; ; inferior ganglion of vagus nerve; ; nipple; ; sperm; ; endothelial cell;
	Top expressed in
	substantia nigra; ; deep cerebellar nuclei; ; otolith organ; ; utricle; ; iris; ; anterior horn of spinal cord; ; nucleus of stria terminalis; ; trigeminal ganglion; ; pontine nuclei; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	catalytic activity; protein binding;
Cellular component	nucleus; cell surface;
Biological process	multicellular organism development; negative regulation of gene expression; metabolism; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23181
	64451
	ENSG00000160305
	ENSMUSG00000020231
	Q14689
	Q8BWT5
NM_001146114; NM_001146115; NM_001146116; NM_015151; NM_206889;
	NM_206890; NM_206891; NM_001353942; NM_001353943; NM_001353944
	NM_001081419
NP_001139587; NP_001139588; NP_055966; NP_996772; NP_996773;
	NP_996774; NP_001340871; NP_001340872; NP_001340873
	NP_001074888
	Wikidata
View/Edit Human	View/Edit Mouse

Disco-interacting protein 2 homolog A is a protein that in humans is encoded by the DIP2A gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020231 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)".

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins". Brain Res. Dev. Brain Res. 130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124.
Wang Z, Tseng CP, Pong RC, et al. (2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Mukhopadhyay M, Pelka P, DeSousa D, et al. (2002). "Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog". Gene. 293 (1–2): 59–65. doi:10.1016/S0378-1119(02)00694-7. PMID 12137943.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Casadei R, Strippoli P, D'Addabbo P, et al. (2004). "mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs". Gene. 321: 185–93. doi:10.1016/S0378-1119(03)00835-7. hdl:11586/196824. PMID 14637006.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Winnepenninckx B, Debacker K, Ramsay J, et al. (2007). "CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1". Am. J. Hum. Genet. 80 (2): 221–31. doi:10.1086/510800. PMC 1785358. PMID 17236128.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160305 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020231 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)".

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[2]

[3]

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[5]

DIP2A

See also

References

Further reading

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