DCP2

This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.

DCP2
Identifiers
Aliases	DCP2, NUDT20, decapping mRNA 2
External IDs	OMIM: 609844; MGI: 1917890; HomoloGene: 13968; GeneCards: DCP2; OMA:DCP2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.2 Start 112,976,702 bp[1] End 113,022,195 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 44,513,569 bp[2] End 44,558,036 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte trabecular bone sperm parietal pleura placenta monocyte bone marrow visceral pleura epithelium of nasopharynx Top expressed in hand otolith organ utricle primitive streak superior cervical ganglion vas deferens condyle vestibular membrane of cochlear duct abdominal wall trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function m7G(5')pppN diphosphatase activity manganese ion binding metal ion binding protein binding exoribonuclease activity, producing 5'-phosphomonoesters RNA binding hydrolase activity 5'-3' exoribonuclease activity telomerase RNA binding Cellular component cytoplasm RISC complex cytosol P-body nucleoplasm cell junction nucleus cytoplasmic ribonucleoprotein granule Biological process mRNA catabolic process regulation of mRNA stability deadenylation-dependent decapping of nuclear-transcribed mRNA exonucleolytic catabolism of deadenylated mRNA histone mRNA catabolic process RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of telomere maintenance via telomerase regulation of telomerase RNA localization to Cajal body Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 167227 70640 Ensembl ENSG00000172795 ENSMUSG00000024472 UniProt Q8IU60 Q9CYC6 RefSeq (mRNA) NM_001242377 NM_152624 NM_027490 RefSeq (protein) NP_001229306 NP_689837 NP_081766 Location (UCSC) Chr 5: 112.98 – 113.02 Mb Chr 18: 44.51 – 44.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.^[5][6][7]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[7]

Interactions

DCP2 has been shown to interact with DCP1A^[8] and UPF1.^[6][9]

References

1. GRCh38: Ensembl release 89: ENSG00000172795 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024472 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (October 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme". Proceedings of the National Academy of Sciences of the United States of America. 99 (20): 12663–12668. Bibcode:2002PNAS...9912663W. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
6. Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
7. "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
8. Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
9. Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–687. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.

Further reading

• Ueno K, Kumagai T, Kijima T, Kishimoto T, Hosoe S (January 1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer". Human Genetics. 102 (1): 63–68. doi:10.1007/s004390050655. PMID 9490301. S2CID 36201527.
• van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Séraphin B (December 2002). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". The EMBO Journal. 21 (24): 6915–6924. doi:10.1093/emboj/cdf678. PMC 139098. PMID 12486012.
• Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–1501. doi:10.1017/S1355838202021726. PMC 1370355. PMID 12515382.
• Grzymski EC (June 2003). "Visualizing an mRNA destruction line". Nature Structural Biology. 10 (6): 416. doi:10.1038/nsb0603-416. PMID 12768200. S2CID 40900780.
• Piccirillo C, Khanna R, Kiledjian M (September 2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2". RNA. 9 (9): 1138–1147. doi:10.1261/rna.5690503. PMC 1370477. PMID 12923261.
• Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–687. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
• Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". The Journal of Cell Biology. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M (September 2004). "Functional analysis of mRNA scavenger decapping enzymes". RNA. 10 (9): 1412–1422. doi:10.1261/rna.7660804. PMC 1370627. PMID 15273322.
• Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (July 2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies". Nature Cell Biology. 7 (7): 719–723. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (December 2005). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Molecular Cell. 20 (6): 905–915. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
• Wichroski MJ, Robb GB, Rana TM (May 2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLOS Pathogens. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.
• Chu CY, Rana TM (July 2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54". PLOS Biology. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.