After studying pediatrics in Vienna and Breslau, Grulee returned to Chicago where he taught briefly at Northwestern University Medical School before taking up a teaching position at Rush Medical College in 1908.[2] He remained at Rush for over 30 years and was eventually made a clinical professor and head of the department of pediatrics in 1942; he was also made a professor of pediatrics at the University of Illinois College of Medicine in 1941. As a clinical pediatrician, he was the chief of pediatrics at Chicago's Presbyterian Hospital and a consulting pediatrician at Saint Francis Hospital of Evanston.[1]
Grulee was involved in numerous pediatric societies in the United States and internationally. In 1911, he helped to establish the now-defunct Central States Pediatric Society and served as president in 1921.[2] He was a founding member of the American Academy of Pediatrics in 1930, and served as the organization's first executive secretary until his retirement in 1951.[1][3] Upon his retirement, the Grulee Award was created to honor individuals who have made "outstanding" contributions to the organization.[4]
He was also involved in the American Pediatric Society, serving as a member of the council and as president of the society in 1938.[1] He wrote and co-wrote textbooks on Infant Feeding (1912), the Newborn (1926), and The Child in Health and Disease (1950).[2]
Grulee died on October 24, 1962, in Evanston, Illinois.[1][2] He died while attending a dinner hosted by the executive board of the American Academy of Pediatrics in his honor.[1][5]