Prof. Mummery has pioneered studies on cardiomyocytes from human embryonic stem cells (hPSC)[3] and was among the first to inject them in mouse heart after myocardial infarction.[4] Mummery was the first to derive human-induced pluripotent stem cells (hiPSC) in Netherlands and is leading in their use for cardiovascular disease modelling and safety pharmacology.[5] In 2010, she established the LUMC hiPSC core facility.[6]
From 1978 to 1980, Mummery worked as a Postdoctoral fellow at the Royal Society, UK working on "Ion transport, differentiation and the cell cycle in neuroblastoma cells”.[8] In 1981, she continued with a Postdoctoral fellowship at the Hubrecht Institute (KNAW), Utrecht, working on neuroblastoma and embryonal carcinoma cells as screens for teratogens[9] before being appointed tenured staff scientist working on developmental biology, differentiation and stem cells in 1985. In 1993, Prof. Mummery became a group leader working on TGFβ and BMP signalling in mouse development using cardiomyogenesis and vasculogenesis in mouse and human (embryonic) stem cells as models. In 2007, Mummery was a visiting professor jointly at the Harvard Stem Cell Institute (HSCI) and the Radcliffe Institute working on to engineer cardiac grafts.[10]
Prof. Mummery is part of five different patents on differentiation of cardiomyocytes and hESC.
GB patent 2394958A, Mummery, Christine Lindsay, "Methods of inducing differentiation of stem cells", published 22 July 2002
AU patent 2004219990A1, Mummery, Christine Lindsay, "Differentiation of human embryonic stem cells to cardiomyocytes", published 22 July 2002
WO patent 2004110912A2, Steinhardt, Mark John, "Applicator for and method of applying a sheet material to a substrate", published 23 December 2004
GB patent 2415437A, Doevendans, Petrus Adrianus; Mummery, Christine Lindsay; Tertoolen, Leon Gerardus Joseph, "Differentiation of human embryonic stem cells to cardiomyocytes", published 28 December 2005
WO patent 2006066320A1, Mummery, Christine Lindsay; Passier, Robert, "Differentiation of human embryonic stem cells and cardiomyocytes and cardiomyocyte progenitors derived therefrom", published 29 June 2006
GB patent 2429718A, Mummery, Christine Lindsay; Passier, Robert, "Improved cardiomyocyte differentiation", published 31 May 2004
Books
Mummery co-authored “Stem Cells, 2nd edition scientific facts and Fiction” (Elsevier 2014).[16] This second edition contains introduction to embryonic and iPS cells and stem cells. It also features additional information on "organs on chips" and adult progenitor cells.
^van Laake, Linda W.; Passier, Robert; Monshouwer-Kloots, Jantine; Verkleij, Arie J.; Lips, Daniel J.; Freund, Christian; den Ouden, Krista; Ward-van Oostwaard, Dorien; Korving, Jeroen; Tertoolen, Leon G.; van Echteld, Cees J. (1 October 2007). "Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction". Stem Cell Research. 1 (1): 9–24. doi:10.1016/j.scr.2007.06.001. ISSN1873-5061. PMID19383383.
^"Christine Mummery". Faculty of Pharmacy and Pharmaceutical Sciences. Retrieved 12 December 2019.
^Mummery, C. L.; Boonstra, J.; van der Saag, P. T.; de Laat, S. W. (July 1982). "Regulation of the cell cycle in neuroblastoma cells: the role of ion transport". Cell Biology International Reports. 6 (7): 654. doi:10.1016/0309-1651(82)90129-1. ISSN0309-1651. PMID6290085.
^Mummery, C. L.; Brink, C. E. van den; Saag, P. T. van der; Laat, S. W. de (1984). "A short-term screening test for teratogens using differentiating neuroblastoma cells in vitro". Teratology. 29 (2): 271–279. doi:10.1002/tera.1420290213. ISSN1096-9926. PMID6740511.
^"Christine Mummery". Radcliffe Institute for Advanced Study at Harvard University. 16 March 2012. Retrieved 12 December 2019.