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Charles Hughes may refer to:

Politics

Charles Hughes (representative) (1822–1887), U.S. Representative from New York
Charles Evans Hughes (1862–1948), Chief Justice of the U.S. Supreme Court, Secretary of State, governor of New York
Charles Evans Hughes Jr. (1889–1950), U.S. Solicitor General
Charles J. Hughes Jr. (1853–1911), U.S. Senator from Colorado

Charles James Hughes (footballer) (1853–1916), English footballer, referee, and co-founder of Northwich Victoria Football Club
Charlie Hughes (baseball) (1906–1981), American baseball player
Charles Hughes (football manager) (1933–2024), English football coach and author
Charlie Hughes (footballer, born 1939), English football goalkeeper
Charlie Hughes (footballer, born 2003), English football centre-back for Wigan
Chuck Hughes (1943–1971), American football player

Charles Hughes (actor), actor who played Young Peter Pettigrew in Harry Potter and the Order of the Phoenix
Charlie Hughes (audio engineer) (born 1965), American audio engineer and inventor
Charles Hughes (Royal Navy officer) (died 1819), British Royal Navy officer
Charles A. Hughes (1881–1953), Detroit businessman and ice hockey executive
Charles Evans Hughes III (1915–1985), U.S. architect
Charles Frederick Hughes (1866–1934), U.S. Navy admiral
Chuck Hughes (chef) (born 1976), French-Canadian chef, television personality, and restaurateur